Vascular effects of continuous hyperbaric oxygen exposure: experimental outlook

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dc.contributor.authorYavuz, Celal
dc.contributor.authorKarahan, Oğuz
dc.contributor.authorAkkaya, Özgür
dc.date.accessioned2023-07-31T13:10:52Z
dc.date.available2023-07-31T13:10:52Z
dc.date.issued2023
dc.departmentALKÜ, Fakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractHyperbaric oxygen (HBO) treatment aims to restore tissue oxygenation by inhaling 100% oxygen in pressure rooms. Although beneficial effects have been reported with regard to re-oxygenated ischemic tissues, conflicting findings have been presented concerning the paradoxical tissue response following reperfusion and/or the different responses of non-ischemic normal tissues to increased oxygen exposure. The present study sought to experimentally investigate the impact of continuous HBO treatments on normal aortic tissue. New Zealand rabbits were placed in pressure rooms for 90 minutes per day under 2.5 atmospheric pressure and exposed to HBO for 28 days. Normal structural histology was obtained in the control group. Foam cells were detected in the aortic intimae, thickening and undulation were visualized in the endothelium, and localized separations were observed in the tunica media in the study group compared with the control group. Moreover, salient vasa vasorum was detected in the study group via histopathology. These findings suggest that continuous HBO exposures disrupt the normal vascular structure of a healthy aorta. © 2023 Wolters Kluwer Medknow Publications. All rights reserved.
dc.identifier.doi10.4103/2045-9912.345175
dc.identifier.endpage201en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage198en_US
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85152980045&origin=resultslist&sort=plf-f&src=s&nlo=&nlr=&nls=&sid=20c4fe371b9b908d4f7e419f791331ff&sot=aff&sdt=cl&cluster=scofreetoread%2c%22all%22%2ct&sl=72&s=AF-ID%28%22Alanya+Alaaddin+Keykubat+University%22+60198720%29+AND+SUBJAREA%28MEDI%29&relpos=25&citeCnt=0&searchTerm=
dc.identifier.urihttps://hdl.handle.net/20.500.12868/2338
dc.identifier.urihttps://journals.lww.com/mgar/fulltext/2023/13040/vascular_effects_of_continuous_hyperbaric_oxygen.8.aspx
dc.identifier.volume13en_US
dc.indekslendigikaynakScopus
dc.language.isoen
dc.relation.ispartofMedical Gas Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAorta
dc.subjectHealthy tissue
dc.subjectHistopathology
dc.subjectHyperbaric oxygen
dc.subjectIncreased oxygen exposure
dc.subjectPeriodical treatment
dc.subjectVascular damage
dc.titleVascular effects of continuous hyperbaric oxygen exposure: experimental outlook
dc.typeArticle

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