Analysis of factors associated with the development of myelofibrosis in polycythemia vera and essential thrombocythemia patients: a single-center experience

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dc.contributor.authorTığlıoğlu, Pınar
dc.contributor.authorAlbayrak, Murat
dc.contributor.authorYıldız, Abdulkerim
dc.contributor.authorTığlıoğlu, Mesut
dc.contributor.authorSağlam, Buğra
dc.contributor.authorAras, Merih Reis
dc.contributor.authorYılmaz, Fatma
dc.contributor.authorMaral, Senem
dc.contributor.authorÖztürk, Hacer Berna Afacan
dc.contributor.authorMalkan, Ümit Yavuz
dc.date.accessioned2023-10-02T06:33:37Z
dc.date.available2023-10-02T06:33:37Z
dc.date.issued2022
dc.departmentALKÜ
dc.description.abstractIn some patients with chronic myeloproliferative neoplasms, myelofibrosis (MF) develops as natural evolution of the disease. The aim of this study was to analyze predictive factors that may cause MF in polycythemia vera (PV) and essential thrombocythemia (ET) patients. This retrospective study was conducted on PV and ET patients who attended our hospital between 2008 and 2019. The development of MF during follow-up was recorded, and comparisons were made of the patients who developed MF and those who did not develop MF. Evaluation was made of 126 ET and 105 PV patients. During follow-up period, MF had developed 5.7% of PV and 7.1% of ET patients. It was determined that JAK-2 mutant allele burden, lymphocyte count, vitaminB12 levels, and grade of bone marrow fibrosis at diagnosis had statistically significant impact on the development of MF in all patients. In the logistic-regression analysis, it was found that initial hemoglobin, hematocrit, neutrophil-to-lymphocyte ratio, and monocyte count for PV patients; vitaminB12, the presence of splenomegaly; and BM fibrosis at diagnosis for ET patients have statistically significant effect on MF development. The results of the current study demonstrated that some parameters especially vitamin B12 levels can be used as predictive markers for the development of MF.
dc.identifier.endpage93en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ4
dc.identifier.startpage83en_US
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85127302283&origin=resultslist&sort=plf-f&src=s&nlo=&nlr=&nls=&sid=20c4fe371b9b908d4f7e419f791331ff&sot=aff&sdt=cl&cluster=scofreetoread%2c%22all%22%2ct&sl=72&s=AF-ID%28%22Alanya+Alaaddin+Keykubat+University%22+60198720%29+AND+SUBJAREA%28MEDI%29&relpos=53&citeCnt=0&searchTerm=
dc.identifier.urihttps://hdl.handle.net/20.500.12868/2361
dc.identifier.urihttps://link.springer.com/article/10.1007/s12308-022-00488-6
dc.identifier.volume15en_US
dc.indekslendigikaynakScopus
dc.language.isoen
dc.relation.ispartofJournal of Hematopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPolycythemia vera
dc.subjectEssential thrombocythemia
dc.subjectMyelofbrosis
dc.subjectPredictive factors
dc.titleAnalysis of factors associated with the development of myelofibrosis in polycythemia vera and essential thrombocythemia patients: a single-center experience
dc.typeArticle

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