Anti-aging and Antioxidant Activities of Ethanol and Three-phase Partitioned Extracts of Inula viscosa

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dc.contributor.authorUckaya, Fatih
dc.date.accessioned2026-01-24T12:29:27Z
dc.date.available2026-01-24T12:29:27Z
dc.date.issued2023
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractInula viscosa is a plant commonly used to treat inflammation, germicide, expectorant, cough reducer, diuretic, anemia, and cancer. In addition to its medicinal effect, this plant has been preferred because it is thought to be a free radical scavenger and anti-aging effect due to its phenolic compounds. The aim of the study was to determine whether the plant has antioxidant and anti-aging potential. The plant was extracted with both the traditional solvent extraction method with ethanol and the novel three-phase partitioned (TPP) system, and the two methods were compared. The methods of DPPH free radical scavenging, ABTS cation radical scavenging, superoxide anion radical scavenging, and reduction of copper and iron ions were used to determine the antioxidant effects of the obtained extracts. In addition, elastase enzyme inhibition was studied to investigate the anti-aging potential. TPP method (23.9% yield) was performed at a higher yield than the solvent extraction (8.99% yield). The ethanolic extract and TPP extract of plant inhibited the DPPH free radical with IC50=0.27 mu g/mL and IC50=0.026 mu g/mL, and ABTS cation radical with IC50=0.28 mu g/mL and IC50=0.13 mu g/mL, and superoxide anion radical with IC50=3.53 mu g/mL and IC50=2.43 mu g/mL, respectively. According to the elastase inhibition results, IC50=3.11 mu g/mL for ethanol extract and IC50=3.05 mu g/mL for TPP extract were obtained. Both extracts of I. viscosa showed antioxidant and anti-aging effects at levels close to the standards. In addition, according to the results, TPP extract was found to be more effective than ethanol extract.
dc.description.sponsorshipBEZMIALEM VAKIF UNIVERSITY [1.2017/32]
dc.description.sponsorshipThis research was funded by BEZMIALEM VAKIF UNIVERSITY, grant number 1.2017/32.
dc.identifier.doi10.33263/BRIAC133.246
dc.identifier.issn2069-5837
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85134154308
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.33263/BRIAC133.246
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5371
dc.identifier.volume13
dc.identifier.wosWOS:000838722800006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAmg Transcend Assoc
dc.relation.ispartofBiointerface Research in Applied Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectInula viscosa
dc.subjectantioxidant
dc.subjectanti-aging
dc.subjectthree-phase partitioning
dc.subjectsolvent extraction
dc.titleAnti-aging and Antioxidant Activities of Ethanol and Three-phase Partitioned Extracts of Inula viscosa
dc.typeArticle

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