Protective Effects of Lumbricus Extract on the Antioxidant System and Liver in an Experimentally Created Liver Ischemia Reperfusion Injury Model in Rats

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dc.authorid0000-0002-1120-1874
dc.contributor.authorOz, Semih
dc.contributor.authorYildiz, Fatma
dc.contributor.authorSenturk, Hakan
dc.contributor.authorUstuner, Mehmet Cengiz
dc.contributor.authorDonmez, Dilek Burukoglu
dc.contributor.authorKus, Gokhan
dc.contributor.authorOzbayer, Cansu
dc.date.accessioned2026-01-24T12:29:03Z
dc.date.available2026-01-24T12:29:03Z
dc.date.issued2023
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractIn this experimental study, we investigated the effects of Lumbricus extract on biochemical and histological markers of liver IR injury model in rats. A total of 10-12-weeks old, 250-300 g Sprague Dawley male rats were divided into groups of five (n = 7). Group I (Sham), Group II (IR), Group III (IR + 10 mg/kg Lumbricus extract), Group IV (IR + 20 mg/kg Lumbricus extract), and Group V (IR + 40 mg/kg Lumbricus extract) were marked, respectively. Lumbricus extract was dissolved with saline and administered orally. All rats except in Group I were applied ischemia for 45 minutes and reperfusion for 24 hours. The data obtained at the end of the experiment were evaluated by histological and biochemical methods, where we investigated catalase (CAT) superoxide dismutase (SOD) enzyme activity and malondialdehyde (MDA) levels, as well as a histological examination of liver tissue samples. When MDA enzyme activity levels were compared with the sham and Lumbricus extract groups, it was found to be significantly higher than the IR group. SOD and CAT activity enzyme levels were found to be significantly lower. Our findings showed that Lumbricus extract could have a protective effect against experimentally induced IR injury in the liver by increasing antioxidant enzyme levels and decreasing lipid peroxidation and liver injury.
dc.identifier.doi10.1134/S1062359022602592
dc.identifier.endpage283
dc.identifier.issn1062-3590
dc.identifier.issn1608-3059
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85152250710
dc.identifier.scopusqualityQ4
dc.identifier.startpage276
dc.identifier.urihttps://doi.org/10.1134/S1062359022602592
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5104
dc.identifier.volume50
dc.identifier.wosWOS:000967779800010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherPleiades Publishing Inc
dc.relation.ispartofBiology Bulletin
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectischemia-reperfusion
dc.subjectliver
dc.subjectlumbricus extract
dc.subjectportal vein
dc.subjectproper hepatic artery
dc.titleProtective Effects of Lumbricus Extract on the Antioxidant System and Liver in an Experimentally Created Liver Ischemia Reperfusion Injury Model in Rats
dc.typeArticle

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