Effects of long term sildenafil on the acute phase of Peyronie’s disease in a combination treatment
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Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objectives: The aim of this study was to Summary investigate the impact of the addition of 50 mg daily sildenafil to pentoxifylline-colchicine combination therapy on the Peyronie's plaque features in patients with the acute phase of Peyronie's disease (PD). Methods: In this retrospective and non-randomized clinical study, patients were divided into 2 groups as group 1; (n = 107) who received colchicine and pentoxyfillin plus 50 mg daily oral sildenafil, and as group 2; (n = 79) who received only colchicine and pentoxyfillin. Patients were compared in terms of degree of curvature, pain in erection and erectile function at the baseline and at 6-month follow up. Pain in erection and erectile function were evaluated by visual Analogue Scale (EF-VAS), and the shortened version of the International Index of Erectile Function (IIEF-5). Improvement in the degree of curvature and change in EF-VAS scores were primary endpoints of the study. Change in IIEF-5 score was the secondary endpoint of the study. Results: The two groups were statistically similar in terms of demographics and baseline features of PD. A statistically significant reduction in degree of curvature and EF-VAS scores was shown in group 1 compared to group 2.There was also a significantly higher IIEF-5 score in group 1 compared to group 2. No significant side effects were detected in both groups during treatment period. Conclusions: Adding sildenafil to pentoxifylline-colchicine combination treatment seems to improve PD related symptoms in the acute phase PD. PDE5i may contribute to relieve the Peyronie's symptoms in ED patients through their antifibrotic effects.
Açıklama
Anahtar Kelimeler
Peyronie, Oral treatment, Fibrosis, Antifibrotic treatment
Kaynak
Archivio Italiano di Urologia e Andrologia
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
94
Sayı
3
Künye
Bağlantı
https://www.scopus.com/record/display.uri?eid=2-s2.0-85138631402&origin=resultslist&sort=plf-f&src=s&nlo=&nlr=&nls=&sid=20c4fe371b9b908d4f7e419f791331ff&sot=aff&sdt=cl&cluster=scofreetoread%2c%22all%22%2ct&sl=72&s=AF-ID%28%22Alanya+Alaaddin+Keykubat+University%22+60198720%29+AND+SUBJAREA%28MEDI%29&relpos=75&citeCnt=0&searchTerm=
https://hdl.handle.net/20.500.12868/2400
https://www.pagepressjournals.org/index.php/aiua/article/view/aiua.2022.3.319
https://hdl.handle.net/20.500.12868/2400
https://www.pagepressjournals.org/index.php/aiua/article/view/aiua.2022.3.319
