Screening of the AhR- and Nrf2-linked transcriptional activities of some cruciferous vegetables and nuts in human intestinal epithelial cells as foods containing endogenous AhR ligand precursors

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dc.contributor.authorToydemir, Gamze
dc.date.accessioned2026-01-24T12:31:26Z
dc.date.available2026-01-24T12:31:26Z
dc.date.issued2022
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractCruciferous vegetables and nuts are rich in indole-3-carbinol (I3C) and L-tryptophan (L-Trp), respectively, which can be converted upon ingestion into AhR ligands. Activation of AhR by dietary ligands contributes to unlocking its therapeutic potential in gastrointestinal homeostasis. In this study, some cruciferous vegetables (cabbage (red and white), cauliflower) and nuts (sunflower seed kernel, pistachio, cashew, walnut) were investigated for their effects on AhR- and Nrf2-mediated gene expression by using an in vitro digestion/Caco-2 cell culture model. Nuts induced AhR-pathway in a directly proportional manner with their L-Trp contents (sunflower induced the highest (5.3-fold) CYP1A1 expression). Nuts also showed Nrf2-dependent activities, although L-Trp standard did not. Vegetables activated only AhR-pathway, same with I3C standard, and red cabbage induced the highest CYP1A1 expression (9.6-fold). Results suggested the contribution of L-Trp and I3C in AhR-dependent activities of nuts and vegetables, respectively, although there appeared other bioactives to be identified in overall health aspects of these foods.
dc.identifier.doi10.1080/08905436.2022.2028263
dc.identifier.endpage112
dc.identifier.issn0890-5436
dc.identifier.issn1532-4249
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85128278902
dc.identifier.scopusqualityQ2
dc.identifier.startpage93
dc.identifier.urihttps://doi.org/10.1080/08905436.2022.2028263
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5874
dc.identifier.volume36
dc.identifier.wosWOS:000777843500001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofFood Biotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectCruciferous vegetables
dc.subjectnuts
dc.subjectL-tryptophan
dc.subjectindole-3-carbinol
dc.subjectAhR
dc.subjectNrf2
dc.subjectCaco-2
dc.subjectRT-qPCR
dc.titleScreening of the AhR- and Nrf2-linked transcriptional activities of some cruciferous vegetables and nuts in human intestinal epithelial cells as foods containing endogenous AhR ligand precursors
dc.typeArticle

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