Carvacrol enhances the sensitıvity of cetuximab in lung cancer cells through inducing apoptosis and cell cycle arrest

Basit Öğe Kaydı
dc.contributor.authorErdogan, Ayse
dc.contributor.authorKoras, Rahime Aybike
dc.date.accessioned2026-01-24T12:29:27Z
dc.date.available2026-01-24T12:29:27Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractThe intention of this work was to analyze that carvacrol could enhance cancer-inhibiting potency of cetuximab (monoclonal antibody) in lung cancer cells. The combination of cetuximab and carvacrol was found to co-operatively suppress cell proliferation by enhancing apoptosis and inducing cell cycle arrest in A-549 and H1299 cells. Furthermore, the combination therapy triggered cell death by inducing membrane disruption. The most effective combinations were IC10 cetuximab + IC10 carvacrol for A-549 and IC20 cetuximab + IC10 carvacrol for H1299 (CI = 2.0). LDH activity increased by 101% in A-549 and 239% in H1299 (p<0.05). Caspase-3 activity rose by 1.6-fold in A549 and 1.4-fold in H1299 (p<0.05). The combination decreased PCNA, topoisomerase II-alpha, and cyclins D1, D2, E, A, and B (p<0.05). Overall, the combination of carvacrol and cetuximab appears to enhance anti-cancer efficacy and may significantly improve therapeutic outcomes in lung cancer cells.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [1919B012201653]
dc.description.sponsorshipThe author would like to thank the Scientific and Technological Research Council of Turkey (TUBITAK) (1919B012201653) for financial support of this work.
dc.identifier.doi10.3329/bjp.v20i1.80949
dc.identifier.issn1991-007X
dc.identifier.issn1991-0088
dc.identifier.issue1
dc.identifier.scopus2-s2.0-105005893503
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.3329/bjp.v20i1.80949
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5372
dc.identifier.volume20
dc.identifier.wosWOS:001480746800004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherBangladesh Pharmacological Soc
dc.relation.ispartofBangladesh Journal of Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectGrowth-Factor Receptor
dc.subjectMonoclonal-Antibody
dc.subjectNeck-Cancer
dc.subjectChemical-Composition
dc.subjectEssential Oils
dc.subjectEgfr
dc.subjectExpression
dc.subjectAntioxidant
dc.subjectChemotherapy
dc.subjectInhibition
dc.titleCarvacrol enhances the sensitıvity of cetuximab in lung cancer cells through inducing apoptosis and cell cycle arrest
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu