Protective Effects of Selenium against Acrylamide-Induced Hepatotoxicity in Rats

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dc.contributor.authorSozen, Mehmet Enes
dc.contributor.authorSavas, Hasan Basri
dc.contributor.authorCuce, Gokhan
dc.date.accessioned2026-01-24T12:29:23Z
dc.date.available2026-01-24T12:29:23Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractAcrylamide (ACR) is an organic chemical widely consumed worldwide, depending on the diet. ACR has toxic effects on the liver and other organs due to oxidative damage. The research is aimed to determine the effects of Selenium (Se) against ACR toxicity. 32 Wistar albino male rats were divided into Control, ACR, Se, and ACR+Se groups. After slaughter on the 28 th day, the blood samples taken from the animals were tested for total oxidant status (TOS) and total antioxidant status (TAS) to assess oxidative stress. The liver tissue sections were evaluated for lymphocyte infiltration, hepatocyte degeneration, sinusoid dilatation, and congestion. IL-6, Bax, and Bcl-2 expression were evaluated with immunohistochemistry. While the ACR group's TOS and oxidative stress index (OSI) values were significantly higher than the control group's, there was no significant difference in the ACR+Se group's TOS and OSI values. The ACR group had a considerably higher histopathological score than the other groups. ACR increased IL-6, and Bax levels and decreased Bcl-2 levels compared to the control, Se, and ACR+Se groups. ACR increased oxidative stress significantly caused toxic effects, inflammation, and cell death in the liver. On the other hand, Se oral supplementation may protect against oxidative stress, toxic effects, inflammation, and cell death induced by ACR in the liver.
dc.description.sponsorshipAlanya Alaaddin Keykubat University Scientific Research Projects Coordination Office [2019-04-01-MAP03]
dc.description.sponsorshipThe authors gratefully acknowledge the Alanya Alaaddin Keykubat University Scientific Research Projects Coordination Office for financial support and Halil Asc & imath;, Mehtap Savran, Fatma Nihan Cankara, & Idot;brahim Ayd & imath;n Candan, and Yasemin Sahin for contributions. Alanya Alaaddin Keykubat University, Scientific Research Projects Coordination Office, supported this project (Project No: 2019-04-01-MAP03) . The preliminary data of this research were presented in summary at the International Harran Health Sciences Congress and 4th International Hippocrates Congress on Medical and Health Sciences in 2020.
dc.identifier.doi10.29261/pakvetj/2024.153
dc.identifier.endpage279
dc.identifier.issn0253-8318
dc.identifier.issn2074-7764
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85198599169
dc.identifier.scopusqualityQ1
dc.identifier.startpage274
dc.identifier.urihttps://doi.org/10.29261/pakvetj/2024.153
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5333
dc.identifier.volume44
dc.identifier.wosWOS:001283050200009
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherUniv Agriculture, Fac Veterinary Science
dc.relation.ispartofPakistan Veterinary Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectAcrylamide
dc.subjectApoptosis
dc.subjectOxidative damage
dc.subjectSelenium
dc.titleProtective Effects of Selenium against Acrylamide-Induced Hepatotoxicity in Rats
dc.typeArticle

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