Comparison of bone marrow stem cells and cell-derived exosomes on oleic acid-induced lung injury in rats

Basit Öğe Kaydı
dc.authorid0000-0001-5284-7439
dc.contributor.authorOnsoz, E.
dc.contributor.authorAyar, G.
dc.contributor.authorUstuk, Hs
dc.contributor.authorBahar, L.
dc.contributor.authorInce, B.
dc.contributor.authorKoksel, Mo
dc.contributor.authorMaytalman, E.
dc.date.accessioned2026-01-24T12:26:54Z
dc.date.available2026-01-24T12:26:54Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractBackground: Acute lung injury and its complication, acute respiratory distress syndrome, are significant clinical burdens that have a limited number of therapeutic approaches. Among them, stem cells seem to be a promising alternative therapy. In this study, we investigated for the first time and compared bone marrow stem cells (BMSCs) and their exosome fractions on lung injury induced by oleic acid in rats. Methods: We administered oleic acid (60 mg/kg) by intravenous route to induce acute lung injury; thereafter, we intravenously applied rat BMSCs (1 x 10(6)) and exosome fractions (obtained from 1 x 10(6) BMSCs by a commercially available kit) to the tail vein two hours after the oleic acid administration. Twenty-four hours later, the rats were sacrificed by deep anesthesia, and we obtained lung tissues. The examination of hematoxylin and eosin-stained samples was evaluated using the parameters of bleeding, leukocyte infiltration, edema, and hyperplasia. A flow cytometer verified the exosomes obtained from the stem cell culture medium. Results: Administration of stem cells and exosome fractions after lung injury restored all those parameters; however, the regenerative capacity of BMSCs was better than its exosome fraction (p =0.004). Conclusion: Stem cells and their exosome fractions can be regarded as therapeutic alternatives in treating oleic acid- induced lung injury in rats, being rather than exosomes their maternal source; the stem cells seem more potent.
dc.description.sponsorshipMersin Uni-versity Scientific Research Projects Unit [2021-2-TP2-4522]
dc.description.sponsorshipThis study was financially supported by the Mersin Uni-versity Scientific Research Projects Unit (Project No: 2021-2-TP2-4522) . The authors are indebted to Dr. Di-lara Nemutlu Samur for her help in cell culture experi-ments.
dc.identifier.endpage108
dc.identifier.issn1108-4189
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85219496917
dc.identifier.scopusqualityQ3
dc.identifier.startpage100
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5016
dc.identifier.volume28
dc.identifier.wosWOS:001435491500003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherLithographia
dc.relation.ispartofHippokratia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectAcute lung injury
dc.subjectoleic acid
dc.subjectbone marrow stem cells
dc.subjectbone marrow stem cell-derived exosome
dc.subjectacellular therapy
dc.titleComparison of bone marrow stem cells and cell-derived exosomes on oleic acid-induced lung injury in rats
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu