Thiol disulfide balance oxidative stress and paraoxonase 1 activities in children and adolescents aged 6-16 Years with specific learning disorders

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dc.contributor.authorSavaş, Hasan Basri
dc.contributor.authorSayar, Ersin
dc.contributor.authorKara Tayfun
dc.date.accessioned2022-09-14T13:20:59Z
dc.date.available2022-09-14T13:20:59Z
dc.date.issued2021
dc.departmentALKÜ, Fakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractIntroduction: Specific learning disorders (SLD) are some of the most common neurodevelopmental disorders. The aim of this study is to determine the potential relationship between children with SLD and zinc, copper, paraoxonase 1 (PON1), arylesterase (ARY), ischemia-modified albumin, thiol balance, oxidative stress index, total antioxidant status, total oxidant status, and routine biochemical parameters. Methods: All participants were assessed with the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children. Total oxidant status, total antioxidant status, thiol balance, ischemia modified albumin, paraoxonase 1 activity, arylesterase activity, zinc and copper levels were measured by the spectrophotometric methods. Results: Compared to the control, the SLD group had statistically significantly lower values for PON1 antioxidant enzyme activity (p=.045), ARY antioxidant enzyme activity (p<.001), 25 OH Vitamin D (p=.005), reduced thiol ratio (p=.028), thiol oxidation reduction ratio (p=.01), native thiols (p=.024) and significantly higher values for total oxidant status (p=.017), oxidized thiol ratio (p=.028). Conclusion: The relationship between oxidative stress and SLD diagnosis in our results will be very important if it is supported by further new studies. In this case, evaluation of vitamin D, oxidative stress, antioxidant status and thiol balance may come to the agenda in the diagnosis and treatment of SLD.
dc.identifier.doi10.29333/ejgm/10837
dc.identifier.issue3en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12868/1614
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1808869421000124?via%3Dihub
dc.identifier.volume18en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.relation.ispartofElectronic Journal of General Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSpecific learning disorders
dc.subjectOxidant status
dc.subjectAntioxidant status
dc.subject25 OH vitamin D
dc.subjectZinc
dc.subjectCopper
dc.titleThiol disulfide balance oxidative stress and paraoxonase 1 activities in children and adolescents aged 6-16 Years with specific learning disorders
dc.typeArticle

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