Comparison of clinical characteristics of wild-type SARS-CoV-2 and Omicron

dc.contributor.authorKırca, Füsun
dc.contributor.authorAydoğan, Sibel
dc.contributor.authorGözalan, Ayşegül
dc.contributor.authorKayıpmaz, Afşin Emre
dc.contributor.authorÖzdemir, Fatma Ayça Edis
dc.contributor.authorTekçe, Yasemin Tezer
dc.contributor.authorBeşer, İpek Omay
dc.contributor.authorGün, Pınar
dc.contributor.authorÖkten, Rıza Sarper
dc.contributor.authorDinç, Bedia
dc.date.accessioned2023-10-09T06:58:18Z
dc.date.available2023-10-09T06:58:18Z
dc.date.issued2022
dc.departmentALKÜ, Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractOBJECTIVE: This study aimed to investigate the effect of mutations by comparing wild-type SARS-CoV-2 and Omicron regarding clinical features in patients with COVID-19. It also aimed to assess whether SARS-CoV-2 cycle threshold value could predict COVID-19 severity. METHODS: A total of 960 wild-type and 411 Omicron variant patients with positive results in SARS-CoV-2 real-time reverse transcriptase polymerase chain reaction test from oropharyngeal and/or nasopharyngeal samples during their hospital admissions were included in this retrospective study. The reference symptoms of the patients were obtained from the hospital database. The correlation between chest computed tomography findings and the "cycle threshold" of patients with wild-type SARS-CoV-2 was assessed. RESULTS: Cough, fever, shortness of breath, loss of taste and smell, and diarrhea were found to be statistically significantly higher (p=0.001; 0.001; 0.001; 0.001; and 0.006; respectively) in the wild-type cohort, while in the Omicron cohort, sore throat and headache were found to be statistically significantly higher (p=0.001 and 0.003, respectively). An inverse relationship was found between chest computed tomography findings and viral load. CONCLUSION: This study revealed that the Omicron variant tended to infect predominantly the upper respiratory tract and showed decreased lung infectivity, and the disease progressed with a milder clinical course. Therefore, the study showed that the tropism of the virus was changed and the viral phenotype was affected. It was also found that SARS-CoV-2 viral load did not predict COVID-19 severity in patients with wild-type SARS-CoV-2.
dc.identifier.doi10.1590/1806-9282.20220880
dc.identifier.endpage1480en_US
dc.identifier.issue10en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage1476en_US
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85142939475&origin=resultslist&sort=plf-f&src=s&nlo=&nlr=&nls=&sid=20c4fe371b9b908d4f7e419f791331ff&sot=aff&sdt=cl&cluster=scofreetoread%2c%22all%22%2ct&sl=72&s=AF-ID%28%22Alanya+Alaaddin+Keykubat+University%22+60198720%29+AND+SUBJAREA%28MEDI%29&relpos=71&citeCnt=8&searchTerm=
dc.identifier.urihttps://hdl.handle.net/20.500.12868/2396
dc.identifier.urihttps://www.scielo.br/j/ramb/a/bBWKmYrJLynmP8BhFsyB9kr/?lang=en
dc.identifier.volume68en_US
dc.indekslendigikaynakScopus
dc.language.isoen
dc.relation.ispartofRevista da Associacao Medica Brasileira
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCoronavirus
dc.subjectCOVID-19
dc.subjectSARS-CoV-2 variants
dc.subjectViral load
dc.titleComparison of clinical characteristics of wild-type SARS-CoV-2 and Omicron
dc.typeArticle

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