Risk factors for white matter lesions in migraine patients: Insights for prevention and management

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dc.authorid0000-0002-4405-521X
dc.contributor.authorYilmaz, Gulcan Gocmez
dc.contributor.authorYilmaz, Ibrahim Arda
dc.contributor.authorOzge, Aynur
dc.contributor.authorSengul, Merve Turkegun
dc.date.accessioned2026-01-24T12:26:45Z
dc.date.available2026-01-24T12:26:45Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractBackground & Objective: White matter lesions (WML) are commonly observed in cerebral Magnetic Resonance Imaging scans of individuals with migraine. However, the exact causes of these lesions in migraine patients remain unclear. This study aims to identify and assess risk factors associated with WML in migraine patients. Methods: Our study included 63 migraine patients with and 64 patients without WML. We compared clinical characteristics and laboratory data between the two groups, including age, gender, age of migraine onset, duration of migraine disease, history of cigarette smoking, presence of hypertension, presence of an aura, attack frequency, photophobia and phonophobia. Results: Multivariate analysis revealed that the risk of developing WML increased two times with age (odds ratio [OR] = 2.00; 95% confidence interval [CI] for OR = 1.24-3.19) and was nearly five times higher in women (OR = 4.92; 95% CI = 1.14-21.11). Compared to patients experiencing a single attack a month, those with 2-5 attacks per month had a seven-fold higher risk, while those with more than five attacks per month had a nine-fold higher risk of developing WML (OR = 7.82; 95% Cl = 1.40-43.64, 9.17; 95% CI = 1.59-52.54). Additionally, a 100-unit increase in TG levels doubled the chances of developing WML (OR = 2.22; 95% CI = 1.23-4.00). Conclusion: This study identifies age, female gender, attack frequency, and elevated TG levels as significant risk factors for the development of WML in migraine patients. These findings provide insights for the prevention and management of WML in individuals with migraine.
dc.identifier.doi10.54029/2024vkn
dc.identifier.endpage181
dc.identifier.issn1823-6138
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85192392710
dc.identifier.scopusqualityQ4
dc.identifier.startpage175
dc.identifier.urihttps://doi.org/10.54029/2024vkn
dc.identifier.urihttps://hdl.handle.net/20.500.12868/4903
dc.identifier.volume29
dc.identifier.wosWOS:001274847500019
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAsean Neurological Assoc
dc.relation.ispartofNeurology Asia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectMigraine
dc.subjectwhite matter lesions
dc.subjectmagnetic resonance imaging
dc.subjectattack frequency
dc.titleRisk factors for white matter lesions in migraine patients: Insights for prevention and management
dc.typeArticle

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