Positive effects of meal frequency and calorie restriction on antioxidant systems in rats

Basit Öğe Kaydı
dc.contributor.authorSavaş, Hasan Basri
dc.contributor.authorGültekin, Fatih
dc.contributor.authorÇiriş, İbrahim Metin
dc.date.accessioned2021-02-19T21:16:19Z
dc.date.available2021-02-19T21:16:19Z
dc.date.issued2017
dc.departmentALKÜ
dc.descriptionciris, metin/0000-0002-5619-4989; Gultekin, Fatih/0000-0003-2888-3215
dc.description.abstractOBJECTIVE: In living organisms, there is a balance between the oxidant and antioxidant systems. Reactive products continuously formed by exogenous and endogenous sources are rendered harmless by the antioxidant system. Oxidative stress is an etiological factor in aging and the development of various diseases. In the present study, the aim was to investigate the effects of meal frequency and calorie restriction on oxidant-antioxidant systems in rat serum and tissue. METHODS: Nine adult male Wistar Albino rats were used for the pilot study, and another 24 adult male Wistar Albino rats, also weighing 200 to 250 g each, were included in the main study. The rats were divided into 3 groups based on nutrition: the ad libitum group (AL) (n=8), the 2-meal group (TM) (n=8), and the 2-meal with calorie restriction group (TM-CR) (n=8). Following the 4-week pilot study, nutrition regulation was performed in all groups for 20 weeks, 7 days a week, with 60 minutes allotted per meal. Serum and tissues of rats were isolated at the end of the experiment. Total antioxidant status (TAS) and total oxidant status (TOS) were determined using the Erel method. Oxidative stress index (OSI) was calculated using the formula OSI = TOS/TAS. Liver tissue was examined histopathologically. Statistical analyses were performed using the IBM SPSS Statistics for Windows, Version 20.0 (IBM Corp., Armonk, NY, USA) program. RESULTS: There were significant differences between the AL and TM, and the AL and TM-CR groups in adipose tissue TOS and OSI, and between the AL and TM groups in the liver TAS of the rats (p<0.05). CONCLUSION: Calorie restriction and sparse meal frequency can increase the activity of antioxidants and can reduce oxidative stress. Thus, many diseases caused by oxidative stress may be prevented with the correct regulation of feeding.
dc.description.sponsorshipScientific Research Unit (SDU BAP); Faculty Development Program (OYP Coordination Unit; SDU OYP) of Suleyman Demirel University [SDU BAP 4476-OYP-D2-15]; OYPMinistry of National Education - Turkey [OYP 05333-DR-12]
dc.description.sponsorshipThe study was supported by the Scientific Research Unit (SDU BAP) and Faculty Development Program (OYP Coordination Unit; SDU OYP) of Suleyman Demirel University (Project Numbers: SDU BAP 4476-OYP-D2-15) and OYP (OYP 05333-DR-12) unit).
dc.identifier.doi10.14744/nci.2017.21548
dc.identifier.endpage116en_US
dc.identifier.issn2148-4902
dc.identifier.issue2en_US
dc.identifier.pmid28971167
dc.identifier.startpage109en_US
dc.identifier.urihttps://doi.org/10.14744/nci.2017.21548
dc.identifier.urihttps://hdl.handle.net/20.500.12868/373
dc.identifier.volume4en_US
dc.identifier.wosWOS:000408987200001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthor0-belirlenecek
dc.language.isoen
dc.publisherKare Publ
dc.relation.ispartofNorthern Clinics of Istanbul
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntioxidant status
dc.subjectcaloric restriction
dc.subjectmeal frequency
dc.subjectnutrition
dc.subjectoxidant status
dc.subjectrat
dc.titlePositive effects of meal frequency and calorie restriction on antioxidant systems in rats
dc.typeArticle

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