Vascular and structural alterations of the choroid evaluated by optical coherence tomography angiography and optical coherence tomography after half-fluence photodynamic therapy in chronic central serous chorioretinopathy

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dc.contributor.authorDemirel, Sibel
dc.contributor.authorÖzcan, Gökçen
dc.contributor.authorYanık, Özge
dc.contributor.authorBatıoğlu, Figen
dc.contributor.authorÖzmert, Emin
dc.date.accessioned2021-02-19T21:20:48Z
dc.date.available2021-02-19T21:20:48Z
dc.date.issued2019
dc.departmentALKÜ
dc.description.abstractPurpose: To concurrently evaluate the effect of half-fluence photodynamic therapy (hf PDT) on choriocapillaris (CC) perfusion and choroidal structure in chronic central serous chorioretinopathy (CSC). Methods: This prospective study included 48 eyes of 41 patients with chronic CSC. Enhanced depth imaging optical coherence tomography and optical coherence tomography angiography (OCTA) images were analyzed. Choroidal area (CA), luminal area (LA), and stromal area (SA) were computed using Image J software. Results: One month after hf-PDT, total CA decreased to 1.312 mm 2 from 1.490 mm 2 (p < 0.001), LA decreased to 0.981 mm 2 from 1.097 mm 2 (p < 0.001), and SA decreased to 0.331 mm 2 from 0.393 mm 2 (p < 0.001). In OCTA, the CC flow in the eyes with CSC (17.75 mm 2 ) was statistically significantly lower than the fellow eyes (18.93 mm 2 ) at the baseline visit (p < 0.001). After hf-PDT, the flow in the choriocapillaris statistically significantly increased to 18.81 mm 2 at the first month (p = 0.02). Conclusions: OCTA proves that after hf-PDT a significant increase in CC perfusion occurred at first month. The decrease of the luminal areas in enhanced depth imaging optical coherence tomography is mainly due to a decrease in large-caliber vessels, which indicates that hf-PDT has an effect on larger choroidal vessels and spares CC flow. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature.
dc.identifier.doi10.1007/s00417-018-04226-6
dc.identifier.endpage912en_US
dc.identifier.issn0721-832X
dc.identifier.issue5en_US
dc.identifier.pmid30617579
dc.identifier.scopusqualityQ1
dc.identifier.startpage905en_US
dc.identifier.urihttps://doi.org/10.1007/s00417-018-04226-6
dc.identifier.urihttps://hdl.handle.net/20.500.12868/692
dc.identifier.volume257en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor0-belirlenecek
dc.language.isoen
dc.publisherSpringer Verlag
dc.relation.ispartofGraefe's Archive for Clinical and Experimental Ophthalmology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectChoriocapillaris perfusion
dc.subjectChronic central serous chorioretinopathy
dc.subjectHalf-fluence photodynamic therapy
dc.subjectOptical coherence tomography angiography
dc.titleVascular and structural alterations of the choroid evaluated by optical coherence tomography angiography and optical coherence tomography after half-fluence photodynamic therapy in chronic central serous chorioretinopathy
dc.typeArticle

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