The association between Hba1c levels, olfactory memory and cognition in normal, pre-diabetic and diabetic persons

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dc.contributor.authorYuluğ, Burak
dc.contributor.authorSaatçi, Özlem
dc.contributor.authorIşıklar, Aysun
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorKılıç, Ulkan
dc.contributor.authorOzansoy, Mehmet
dc.contributor.authorKılıç, Ertuğrul
dc.date.accessioned2021-02-19T21:20:48Z
dc.date.available2021-02-19T21:20:48Z
dc.date.issued2020
dc.departmentALKÜ
dc.description.abstractBackground and Aim: Recent data have shown that olfactory dysfunction is strongly related to Alzheimer’s Disease (AD) that is often preceded by olfactory deficits suggesting that olfactory dysfunction might represent an early indicator of future cognitive in prediabetes. Methods: We have applied to a group of normal (n=15), prediabetic (n=16) and type 2 diabetic outpatients (n=15) olfactory testing, 1.5-T MRI scanner and detailed cognitive evaluation including the standard Mini-Mental State Examination (MMSE) form, Short Blessed Test (SBT), Letter Fluency Test (LFT) and the category fluency test with animal, Fruit and Vegetable Naming (CFT). Results: We have shown that Odour Threshold (OT), Discrimination (OD), and Identification (OI) scores and most cognitive test results were significantly different in the prediabetes and diabetes group compared to those in the control group. OD and OT were significantly different between the prediabetes and diabetes group, although the cognitive test results were only significantly different in the prediabetes and diabetes group compared to those in the control group. In evaluating the association between OI, OT, OD scores and specific cognitive tests, we have found, that impaired olfactory identification was the only parameter that correlated significantly with the SBT both in the pre-diabetes and diabetes group. Although spot glucose values were only correlated with OT, HbA1c levels were correlated with OT, OD, and OI, as well as results of the letter fluency test suggesting that HbA1c levels rather than the spot glucose values play a critical role in specific cognitive dysfunction. Conclusion: To the best of our knowledge, this is the first prospective study to demonstrate a strong association between olfactory dysfunction and specific memory impairment in a population with prediabetes and diabetes suggesting that impaired olfactory identification might play an important role as a specific predictor of memory decline. © 2020 Bentham Science Publishers.
dc.identifier.doi10.2174/1871530319666190614121738
dc.identifier.endpage212en_US
dc.identifier.issn1871-5303
dc.identifier.issue2en_US
dc.identifier.pmid31203811
dc.identifier.scopusqualityQ2
dc.identifier.startpage198en_US
dc.identifier.urihttps://doi.org/10.2174/1871530319666190614121738
dc.identifier.urihttps://hdl.handle.net/20.500.12868/697
dc.identifier.volume20en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor0-belirlenecek
dc.language.isoen
dc.publisherBentham Science Publishers
dc.relation.ispartofEndocrine, Metabolic and Immune Disorders - Drug Targets
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCognition
dc.subjectDiabetes
dc.subjectMemory dysfunction
dc.subjectOlfaction
dc.subjectOlfactory memory
dc.subjectPrediabetes
dc.titleThe association between Hba1c levels, olfactory memory and cognition in normal, pre-diabetic and diabetic persons
dc.typeArticle

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