Anesthesia Applications in Experimental Neurological Disease Modeling

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dc.authorid0000-0002-8212-7149
dc.authorid0000-0002-3394-2438
dc.contributor.authorCetinkaya, Ayhan
dc.contributor.authorCelik, Humeyra
dc.date.accessioned2026-01-24T12:29:19Z
dc.date.available2026-01-24T12:29:19Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractNeuroscience, which covers the molecular mechanisms employed by the brain to cause neurological diseases and how they can be treated, remains current as the subject of high-budget investigations to develop early diagnosis and new treatment modalities with multidisciplinary approaches. For this purpose, creating the appropriate model with the correct modality and anesthesia in neurological in vivo experimental models is the most important phase to obtain accurate results and ensure animal welfare. To manage anesthesia in rodents, knowing the physiological characteristics of anesthetics and their risks will strengthen experimental procedures. Among the injectable anesthetics, ketamine, xylazine, and pentobarbital are the most frequently preferred agents for general anesthesia in short surgical procedures. Isoflurane and sevoflurane are inhaler anesthetics that are administered through a vaporizer because they are liquids. Important advantages of inhaled anesthetics, such as rapid induction and rapid withdrawal, make inhaled anesthetics stand out in neuroscience studies. In this review, the properties of frequently used anesthetic agents in rodents, their usage methods, and which model they are preferred will be discussed. For this purpose, the selection of appropriate anesthetics in animal models such as epilepsy, Alzheimer's disease, ischemia-reperfusion injury, traumatic brain injury, ischemic stroke, experimental autoimmune encephalomyelitis, and ophthalmic surgical procedures and their side effects will be reviewed.
dc.identifier.doi10.18678/dtfd.1504037
dc.identifier.endpage35
dc.identifier.issn1307-671X
dc.identifier.scopus2-s2.0-85197523888
dc.identifier.scopusqualityQ3
dc.identifier.startpage30
dc.identifier.urihttps://doi.org/10.18678/dtfd.1504037
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5277
dc.identifier.volume26
dc.identifier.wosWOS:001301551400005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherDuzce Univ, Fac Medicine
dc.relation.ispartofDuzce Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectAnesthesia
dc.subjectneuroscience
dc.subjectin vivo models
dc.titleAnesthesia Applications in Experimental Neurological Disease Modeling
dc.title.alternativeDeneysel Nörolojik Hastalık Modellemelerinde Anestezi Uygulamaları
dc.typeReview Article

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