The Investigation of Leptin (LEP) and Leptin Receptor (LEPR) Gene Variations in Obese Patients

Basit Öğe Kaydı
dc.authorid0000-0003-2615-0202
dc.authorid0000-0003-2433-0277
dc.authorid0000-0002-8338-9546
dc.authorid0000-0001-6741-4345
dc.authorid0000-0001-5824-6159
dc.contributor.authorDurak, Sermin
dc.contributor.authorAksoyer Sezgin, Saadet Busra
dc.contributor.authorCelik, Faruk
dc.contributor.authorDiramali, Murat
dc.contributor.authorYaylim, Ilhan
dc.contributor.authorGurol, Ali Osman
dc.contributor.authorCakmak, Ramazan
dc.date.accessioned2026-01-24T12:30:59Z
dc.date.available2026-01-24T12:30:59Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractObesity is defined as a chronic public health problem that leads to deterioration in metabolic health. The leptin gene (LEP gene rs7799039) and leptin receptor (LEPR gene rs1137101) polymorphisms are thought to potentially be related to the pathophysiology of obesity and its complications. This study aimed to evaluate the role of critical gene polymorphism of the leptin gene in the pathogenesis of obesity. This study consisted of 4 groups including control (n = 49), overweight (n = 50), obese(n = 50), and morbid obesity (n = 49). Real-time polymerase chain reaction was used for distributions of genotypes. We found statistically significant results in terms of genotype distribution of LEP gene and LEPR gene polymorphisms in the study groups (p = 0,031; p < 0,001, respectively) and showed an especially significant relationship between the G allele of the LEPR gene and increased BMI. Moreover, we found that the GG genotype of the LEP gene is statistically significant in terms of BMI in the obesity and morbid obesity groups (p < 0.001). LEP and LEPR genes may serve as significant biomarkers in developing personalized treatments for obesity. Further studies with larger samples will shed light on the pathophysiology of obesity and enhance our understanding of leptin's role in obese patients.
dc.description.sponsorshipResearch Fund of the Scientific and Technological Research Council of Turkey [TUBIdot;TAK 1003]
dc.description.sponsorshipResearch Fund of the Scientific and Technological Research Council of Turkey (TUB & Idot;TAK 1003) (Project No:116E827).
dc.identifier.doi10.1007/s12018-025-09308-8
dc.identifier.issn2948-2437
dc.identifier.issn2948-2445
dc.identifier.issue1
dc.identifier.scopus2-s2.0-105015587654
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1007/s12018-025-09308-8
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5574
dc.identifier.volume23
dc.identifier.wosWOS:001568810200001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofClinical & Translational Metabolism
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectObesity
dc.subjectLeptin
dc.subjectLeptin receptor
dc.subjectPolymorphism
dc.subjectGene
dc.titleThe Investigation of Leptin (LEP) and Leptin Receptor (LEPR) Gene Variations in Obese Patients
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu