Yazar "Gunal, Mehmet Yalcin" seçeneğine göre listele

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    Alzheimer Hastalığı Tedavisine Yönelik Yeni Doğal Bileşiklerin Tanımlanması ve Nörodejenerasyon Üzerindeki Etkilerinin Belirlenmesi
    (2019) Baykal, Ahmet Tarık; Gunal, Mehmet Yalcin; Akgun, Emel; Gurel, Busra
    Alzheimer Hastalığı (AH), yaşlılarda demansın en yaygın formudur ve günümüzde hasta sayısının 18 milyon olduğu ve bu sayının 2050?ye kadar 50 milyona ulaşması tahmin edilmektedir. Dünyada başlıca ölüm sebeplerinden 5. sırada bulunan AH?nin hala tedavisi bulunmamaktadır. Projenin amacı, AH tedavisine yönelik doğal bileşikleri belirlemek ve bu bileşiklerin nörodejenerasyon üzerindeki etkilerini ortaya koymaktır. Bu kapsamda AH tedavisi ic?in umut vaadeden alkaloid ve kumarin biles?ikler izole edildi ve 5XFAD fare modeli u?zerinde no?redejenerasyonu olan etkisi incelendi. Alzheimer Hastalığı tedavisi için umut vaadeden 6 farklı alkaloid ve kumarin bileşik iki farklı dozda, ileri evre 5 ailesel Alzheimer mutasyonu taşıyan 5XFAD transgenik farelere uygulandı. Morris Su Tankı Testi ile bileşiklerin hafıza ve öğrenme üzerine etkileri belirlendi. 6 bileşikten özellikle 1 bileşiğin öğrenme ve hafıza üzerinde iyileştirici etkisi olduğu belirlendi. Bileşiklerin kan beyin bariyerini geçişi MALDI-Görüntüleme ve MRM (TSQ-MS) teknikleri ile incelendi, Bileşik 3?ün kan beyin bariyerini geçtiği tespit edildi. Bileşik enjeksiyonu gerçekleştirilmiş farelerin korteks, hipokampüs ve serebellum beyin bölgelerindeki protein ifade farklılıkları nLC-MS/MS yöntemi ile incelendi. Anlamlı farklılık gösteren proteinler, STRING yazılımı yardımı ile analiz edilerek bileşiklerin muhtemel moleküler çalışma mekanizması ortaya koyuldu.
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    Correlation of some anatomical angles of the shoulder with rotator cuff syndrome
    (Wolters Kluwer Medknow Publications, 2023) Candan, Busra; Torun, Ebru; Dikici, Rumeysa; Avnioglu, Seda; Gunal, Mehmet Yalcin
    Background: Shoulder movement occurs through the coordinated work of muscles, tendons, ligaments, and bones, primarily that affect the glenohumeral joint. Some distances and the angles between the bones forming this joint are important in shoulder pathologies. In this study, we aimed to determine the evaluation of nine different radiological parameters related to acromion and humerus in rotator cuff syndrome and control group patients. Materials and Methods: A total of 400 patients' routine clinic radiographs were retrospectively assessed, which have rotator cuff syndrome (n = 210), and control group (n = 190). We measured the critical shoulder angle (CSA), distance of glenoid-acromion (GA), distance of glenoid-humeral head (GH), acromial index, lateral acromial angle (LAA), total shoulder arthroplasty angle (TSA), reverse shoulder arthroplasty angle (RSA), Point T represents the superior border of the glenoid cavity, Point S represents the inferior border of the glenoid cavity, point R represents the intersection of the supraspinatus fossa line with the glenoid surface. RST angle, and greater tuberosity angle (GTA) angle. We determined the type of acromion. Results: We determined that the GH, TSA, RST, and GTA were significantly different between rotator cuff syndrome and control group patients. When we evaluated the acromion type, Type 2 was the most common type. Different from the literature, when we evaluated the relationship between acromion types and angles, we determined that LAA, GA, and TSA parameters were significantly different between acromion types. Conclusions: In this study, we determined the importance of measurements and angles in rotator cuff syndrome. We think that the relationship between acromion types and parameters can contribute to the literature. Moreover, we believe that our study will contribute to the literature in terms of gathering many angles that are important in shoulder pathologies in a single study.
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    Do trace elements influence quality of life in postmenopausal women with iron deficiency?
    (Dustri-Verlag Dr Karl Feistle, 2020) Cikim, Gurkan; Kilinc, Metin; Gunal, Mehmet Yalcin; Tok, Abdullah; Tolun, Fatma Inanc; Cikim, Nihan
    Objectives: Menopause is defined as the permanent termination of menstruation. In menopause, anemia may occur, and in addition various damages in the body due to free radicals may be seen. Antioxidant molecules are protective against these damages. In this study, we aimed to compare zinc. copper, and malondialdehyde (MDA) levels in postmenopausal women with and without iron deficiency anemia. Materials and methods: Postmenopausal women with iron deficiency anemia (group 1) (n = 30) and without anemia (group 2) (n = 30) were included in the study. Venous blood samples were obtained from the subjects after a fasting period of 12 hours. Hemoglobin, hematocrit, ferritin, MDA, iron, copper, and zinc levels were measured. Data were evaluated using an independent sample t-test. Results: Copper and MDA levels were significantly higher in group I than in group 2; zinc, ferritin, iron. hemoglobin, and hematocrit levels were lower. Conclusion: Nutritional habits have great importance in improving the quality of life in the postmenopausal period. Therefore, we think that MDA levels, which provide information about oxidative damage levels, and trace elements such as zinc, copper, and iron, should be monitored periodically in postmenopausal women.
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    Investigation of The Effect of Adalimumab on Experimental Brain Injury in Mice
    (2019) Gunal, Mehmet Yalcin; Çankaya, Seyda; Tönük, Şükrü Burak; Özdemir, Ekrem Musa; Şakul, Ayşe Arzu Sayın
    Aim: We aimed to investigate the neuroprotective role of adalimumab based onthe hypothesis that \"TNF-alpha inhibitor adalimumab may affect inflammationrelated neuronal injury due to its anti-inflammatory effect\".Methods: To investigate the effects of adalimumab, we induced brain injury inmice using a cold trauma model and evaluated the underlying cell survival/ deathmechanisms via cresyl violet and calculated infarct/edema volume with imageanalyze system.Results: Although our data indicated a tendency to decreased infarct and edemavolume, these findings are not significant statistically.Conclusion: To the best of our knowledge, this is the first study evaluating theneuroprotective effect of adalimumab on injured neurons.
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    Protective Effect of Lutein/Zeaxanthin Isomers in Traumatic Brain Injury in Mice
    (Springer, 2021) Gunal, Mehmet Yalcin; Sakul, Ayse Arzu; Caglayan, Ahmet Burak; Erten, Fusun; Kursun, Oznur Ece Durmaz; Kilic, Ertugrul; Sahin, Kazim
    Previous studies revealed that oxidative stress and inflammation are the main contributors to secondary injury after traumatic brain injury (TBI). In an earlier study, we reported that lutein/zeaxanthin isomers (L/Zi) exert antioxidative and anti-inflammatory effects by activating the nuclear factor-kappa B (NF-kappa B) and nuclear factor-erythroid 2-related factor 2 (Nrf2) pathways. However, its precise role and underlying mechanisms were largely unknown after TBI. This study was conducted to investigate the potential mechanism of L/Zi isomers in a TBI model induced by a cold injury model in mice. To investigate the effects of L/Zi, male C57BL/6j mice-induced brain injury using the cold trauma model was allocated into two groups (n = 7): (i) TBI + vehicle group and (ii) TBI + L/Zi group (20 mg/kg BW). Brain samples were collected 24 h later for analyses. L/Zi given immediately after the injury decreased infarct volume and blood-brain barrier (BBB) permeability; L/Zi treatment also significantly reduced proinflammatory cytokines, including interleukin1 beta (IL-1 beta), interleukin 6 (IL-6), and NF-kappa B levels and increased growth-associated protein 43 (GAP-43), neural cell adhesion molecule (NCAM), brain-derived neurotrophic factor (BDNF), and Nrf2 levels compared with vehicle control. These data suggest that L/Zi improves mitochondrial function in TBI models, possibly decreasing inflammation and activating the Nrf2 pathway.