Yazar "Günizi, Hüseyin" seçeneğine göre listele

Listeleniyor 1 - 12 / 12
  • [ X ]
    Öğe
    A CASE REPORT AND LITERATURE REVIEW OF PRIMARY ADRENOCORTICAL INSUFFICIENCY AS A COMPLICATION OF RHINO-ORBITAL-CEREBRAL MUCORMYCOSIS
    (2025) Eren, Anıl; Kısar, İpek; Kubat, Gözde Orhan; Günizi, Hüseyin
    Backgorund: Despite recent improvements in both diagnosis and treatment, rhino-orbital-cerebral mucormycosis (ROCM) is a life-threatening infection with a high mortality rate. Early diagnosis and treatment are crucial in terms of mortality and morbidity. Case: A 72-year-old female patient was hospitalised with the diagnosis of type 2 diabetes mellitus (DM), allergic asthma, and ROCM and discharged after iv liposomal amphotericin B treatment and surgical debridement. The patient, who was discharged after surgical and medical intervention, died due to the development of primary adrenal insufficiency. Conclusion: Lipid formulations of Amphotericin B and aggressive debridement form the basis of treatment. The most critical decision is whether the orbit should be exenterated or not. The development of side effects related to antifungal treatment has an impact on the mortality and morbidity of patients.
  • [ X ]
    Öğe
    Alerjik rinitli hastalarda HIF1A geni polimorfizmlerinin araştırılması
    (Ağrı İbrahim Çeçen University, 2025) Yaşar, Bünyamin; Günizi, Hüseyin; Ekşi, Durkadın Demir
    Amaç: Alerjik rinit (AR), çevresel alerjenlere karşı IgE aracılı aşırı duyarlılık nedeniyle gelişen kronik inflamatuar bir hastalıktır. Türkiye'de AR prevalansı %11,8 ile %36,4 arasında değişmektedir. Hipoksi ile İndüklenebilir 1-Alfa (HIF1A) geni, hipoksi ve inflamasyonla ilişkili yolların önemli bir rol oynar ve bu genin polimorfizmleri, çeşitli inflamatuar hastalıklarla ilişkilendirilmiştir. Bu çalışma, HIF1A genindeki C1772T ve C111A polimorfizmlerinin AR ile ilişkisinin araştırılmasını amaçlamıştır. Materyal ve Method: Çalışmaya 100 AR hastası ve 100 sağlıklı kontrol dahil edilmiştir. Tek Nükleotid Polimorfizmi (SNP) analizleri, PCR-RFLP kullanılarak yapılmış ve Sanger dizileme ile doğrulanmıştır. Serum total IgE seviyeleri ölçülmüş ve hastalar, hastalık şiddeti ve süresine göre sınıflandırılmıştır. Genotip bulguları, hastaların klinik özellikleriyle karşılaştırılmıştır. Bulgular: C111A polimorfizmi, hasta ve kontrol gruplarında homozigot yabanıl tip (CC) olarak bulunmuştur. C1772T polimorfizmi ise genotip ve alel frekansı açısından hasta ve kontrol gruplarında anlamlı fark göstermemiştir. Alt grup analizlerinde de fark bulunmamıştır. Sonuç: Bu çalışma, HIF1A genindeki bu iki polimorfizmin Türk popülasyonunda AR gelişimiyle ilişkili olmadığını göstermiştir. Ancak literatürde HIF1A mRNA ve protein seviyelerinin AR üzerindeki etkileri gösterilmiştir. Genetik ve çevresel faktörler nedeniyle sonuçların popülasyonlar arasında farklılık gösterebileceği bilinmektedir. HIF1A genindeki alternatif polimorfizmler ve ekspresyon seviyelerinin incelenmesi ile AR ve HIF1A ilişkisinin daha iyi anlaşılabileceği sonucuna varılmıştır.
  • Küçük Resim
    Öğe
    Are Telerehabilitation Exercise Practices Effective in Patients Diagnosed with Benign Paroxysmal Positional Vertigo?
    (2023) Hacıabbasoğlu, Reyyan; Aracı, Ayça; Günizi, Hüseyin
    The aim of this study was to investigate the effectiveness of classical Vestibular Rehabilitation Exercises (Control Group-CG) given as home exercise program and VR + balance exercises (Experimental Group-EG) applied with telerehabilitation method on patients with Benign Paroxysmal Positional Vertigo (BPPV). Material and Methods: The patients were randomly divided into 2 therapy groups in the ALKU Hospital (CG; 21 patients, and EG;22 patients). Pre- and post-test experimental design was adopted and a six-week training was offered. The participants’ balance ability (Romberg, tandem and semi-tandem tests), vertigo severity (Vertigo Symptom Scale-VSS, VAS), vertigo-related disability level (Dizziness Handicap Inventory-DHI), anxiety (Beck Anxiety Inventory-BAI) and quality of life (Vertigo Dizziness Imbalance Questionnaire-VDI) were assessed. Regarding the balance ability, findings in tandem and semi-tandem tests were significantly increased in the EG compared to CG (p < 0.05). According to VAS, the severity of dizziness decreased significantly compared to the CG (p < 0.05). Regarding the DHI score, symptoms of vertigo were reduced considerably after the treatment compared to the CG (p < 0.05). A significant improvement was observed in the quality of life of the EG group according to VDI scoring (p < 0.05). Although gains were observed in both groups, it was observed that the EG group obtained more effective improvement in the severity of vertigo, disability level due to vertigo, and quality of life compared to the home exercise group.These results confirmed the hypothesis that EG applications are effective and clinically applicable in patients with BPPV. © 2023, Association of Otolaryngologists of India.
  • [ X ]
    Öğe
    Investigation of Inflammation and Autophagy due to Biglycanmediated TLR2/4 Signaling in Oral Lichen Planus Tissues
    (2024) Günizi, Özlem Ceren; Günizi, Hüseyin; Ecıroglu, Hamıyet; Yıldız, Fatma
    Objective: Oral lichen planus (OLP) is a chronic oral mucosal disease of unknown etiology. Cellular immune response, basement membrane, and extracellular matrix (ECM) molecules are also noteworthy in the pathogenesis. We aimed to investigate the role of Biglycan (BGN) in Toll-like receptors (TLR)2/4- CD14 and TLR4-CD44 mediated signaling mechanisms in the pathogenesis of OLP. Methods: Twenty-one patients with a previous diagnosis of OLP and 21 patients with normal oral mucosa were included. RNA was isolated from biopsy samples of patients, and the gene expression of BGN, TLR2, TLR4, CD14, and CD44 was analyzed by quantitative real-time polymerase chain reaction and immunohistochemistry. Results: According to our findings, the fold change rates of BGN, TLR2, TLR4, and CD14 mRNA levels in tissues obtained from patients with OLP were higher compared with the control group. TLR2, TLR4, and CD14 fold change rates were statistically significant (p<0.05). CD44 co-receptor mRNA levels were higher in the control group (p<0.05). Similar results were obtained by immunohistochemical analysis. Conclusion: BGN expression has a pro-inflammatory effect in various disease models. The BGN levels in the tissues of patients with OLP were higher than those of the control group, but the difference was not statistically significant. However, TLR2/4-CD14 and CD44 levels were upregulated, as well as CD44 levels were downregulated. We suggest that inflammation signaling is activated and autophagy is inhibited in OLP. BGN-dependent inflammation and autophagy signaling in OLP are evaluated for the first time.
  • [ X ]
    Öğe
    Lack of Association Between FNDC5 Gene Polymorphisms, Serum Irisin Levels and Allergic Rhinitis
    (2023) Eksi, Durkadin Demir; Günizi, Hüseyin
    Aim: Allergic rhinitis (AR) is an inflammatory nasal mucosa disease caused by type 1 immunoglobulin E-mediated reactions to allergen exposure. Irisin is a hormone released by skeletal muscles in response to exercise. There are studies that demonstrate the relationship of irisin with inflammation. We aimed to investigate the potential association between irisin coding fibronectin type III domain 5 (FNDC5) gene polymorphisms, serum irisin levels, and AR. Method: A case-control study was designed, involving 100 AR patients and 100 healthy controls. Genotyping of rs726344 and rs1746661 SNPs within the FNDC5 gene was performed using PCR-RFLP method. Serum irisin levels were measured using ELISA. Results: Genotyping of rs726344 SNP in patients revealed 90% GG and 10% GA genotypes, while in controls, it was 94% GG and 6% GA. The AA genotype was not detected in any case. For rs1746661 SNP, patients had 57% GG, 39% GT, and 4% TT genotypes, while controls had 58% GG, 36% GT, and 6% TT genotypes. No significant difference was found in rs726344 and rs1746661 SNPs between the patients and the control group. Serum irisin level was 406.3±56.09 ng/ml in patients and 354.3±46.06 ng/ml in controls with no significant difference. Conclusion: This is the first study aiming to investigate the relationship between the irisin protein, its encoding gene, and AR. No significant association was identified between FNDC5 gene polymorphisms, serum irisin levels, and allergic rhinitis. While these findings suggest a limited role of these factors in AR, further studies are needed for more comprehensive understanding of the irisin-AR relationship.
  • [ X ]
    Öğe
    Nadir bir olgu: Konjenital fasiyal paralizi
    (Alanya Alaaddin Keykubat Üniversitesi, 2017) Günizi, Hüseyin
        Fasiyal paralizi mimik kaslarını innerve eden fasiyalsinirin felcidir. Yenidoğan dönemindeki fasiyal paralizi genellikle gelişimselveya travmatik olarak gözlenilebilen nadir bir durumdur. Doğum sırasındagelişen travma en sık nedeni olmasına rağmen, bazen genetik sendromlar ve içkulak yapısal anomaliler ile birlikte görülebilmektedir. Ayırıcı tanıdadepresör anguli oris kasının tek taraflı hipoplazisi veya aplazisinin nedenolduğu konjenital asimetrik ağlayan yüz de düşünülmelidir. Doğum travmasınabağlı gözlenen olgularda birkaç hafta içerisinde kendiliğinden düzelmegözlenir. Ancak konjenital gelişim defektleriyle birlikte olan fasiyalparalizilerde prognoz travmatik olanlara göre daha kötüdür. Burada konjenitalfasiyal paralizi ve el parmak anomalisi olan bir olgu sunulmaktadır.
  • [ X ]
    Öğe
    Nazofaringeal kanserlerde prognostik faktörlerin değerlendirilmesi
    (Alanya Alaaddin Keykubat Üniversitesi, 2017) Hasanov, Rüstem; Günizi, Hüseyin; Güney, Kenan
     Amaç: Kliniğimizde teşhisve tedavi edilen nazofaringeal kanserli (NPC) hastaların hayatta kalmasınıetkileyen prognostik faktörleri incelemektir.Yöntemler: Kliniğimizde2009-2013 yılları arasında teşhis ve tedavi edilen nazofaringeal kanserlihastalar geriye dönük olarak incelendi.Bulgular: Çalışmamızda 33hasta erkek (% 73.3), 12 hasta kadın (% 26.6), erkek / kadın oranı 2.75 idi.Ortalama yaş 50,8; En genç hasta 14 ve en yaşlısı 84 yaşında idi. En sıkgörülen neden servikal lenf nodu metastazı (% 66,7) idi. Hastalarımızın%66,6'sında ileri evre tümör vardı (Evre 3-4). Düşük T evresi hastalarında dahauzun sağkalım süresi saptanırken, N-evresi ile sağkalım arasında ilişkisaptanmadı. Histopatolojik tiplerle 2 yıllık sağkalım arasında istatistikselolarak bir ilişki saptanmadı. Genç yaş grubu ve erkek hastalarda daha uzunsağkalım süresi gözlemlendi fakat bu istatistiksel olarak anlamlı değildi.Sonuç: Genç yaş iyiprognostik faktörlerdir, ancak tanıdaki ilerlemiş T ve N evreleri kötüprognostik faktörlerdir. Bu nedenle erken teşhis, tedavi ve sağkalım açısındanönemlidir.
  • [ X ]
    Öğe
    Obstruktif sleep apne ve erektil disfonksiyon arasındaki ilişki
    (Alanya Alaaddin Keykubat Üniversitesi, 2019) Günizi, Hüseyin; Avcı, Suat; Kol, Arif; Yağbasan, Devrim Berna
    Amaç: Obstruktif Sleep Apne Sendromu (OSAS) sık görülen uyku bozukluklarından biridir. Uykuda üst solunum yollarında parsiyel ya da tam obstrüksiyona bağlı gelişen, kronik intermitant hipoksi sonucu sistemik etkileri olan bir hastalıktır. Çalışmamızda OSAS tanısı almış hastalarda Erektil Disfonkiyon (ED) sıklığını saptamak amaçlandı. Gereç ve Yöntem: Çalışmamıza Ekim 2013- Aralık 2015 tarihleri arasında hastanemiz KBB polikliniğine horlama şikayeti ile başvurup polisomnografide OSAS tanısı alan 68 hasta dahil edildi. ED varlığını araştırmak için IIEF -15 (international index erectile dysfunction-15) anket formları dolduruldu. Bulgular: Çalışmadaki 68 erkek hastanın yaşları 25 ile 81 arasında, ortalama yaş 44.75±10,654 idi En düşük AHI değeri 5,1 en yüksek 82,4 ortalama 25.750± 23.226 idi (Tablo 1). IIEF 15 anketine göre çalışmaya katılan hastaların % 67.6 ‘sında ED saptandı. Sonuç: ED, OSAS’ın önemli bir komplikasyonudur ve erkek hastalar için önemli bir sağlık sorunudur. OSAS hastalarında ED mutlaka sorgulanmalıdır.
  • [ X ]
    Öğe
    Tongue solitary angiokeratoma
    (Alanya Alaaddin Keykubat Üniversitesi, 2017) Günizi, Hüseyin; Günizi, Özlem Ceren
    Angiokeratomais a capillary vascular malformation, characterized clinically by solitary ofmultiple papules or plaques. From a clinical point of view, it can show eithera generalized and diffuse form of presentation, or all localized one.Clinically, five varieties are generally recognized: 1. solitary papularangiokeratomas, 2.scrotal or vulvaranjiokeratomas, 3.multiple papular and plaquelike angiokeratoma circumscriptum, 4.bilaterallesions on the dorsum of toes and fingers,5.generalized systemic type angiokeratoma corporis diffusum. Isolated mucosalangiokeratoma of the tongue is extremely rare. We report an unusual case ofsolitary angiokeratoma on the tongue.
  • [ X ]
    Öğe
    Tonsillektomi materyallerinde aktinomiçes
    (Alanya Alaaddin Keykubat Üniversitesi, 2020) Günizi, Özlem Ceren; Günizi, Hüseyin
    Amaç: Tonsillektomi çocuk yaş grubunda en sık yapılan ameliyatlardan birisidir. Actinomiçes türleri Gram-pozitif, spor oluşturmayan fakültatif anaerobik bakterilerdir. Aktinomikoz, subakuttan kronik enfeksiyona kadar apse oluşumu ile karakterize bir hastalıktır.Gereç ve Yöntemler: Ocak 2016 - Ocak 2019 tarihleri arasında Alanya Alaaddin Keykubat Üniversitesi Eğitim ve Araştırma Hastanesinde tonsillektomi uygulanan 185 hastanın tonsillektomi materyalleri ile çalıştık.Bulgular: Tonsillektomi yapılan 98 (% 53) erkek ve 87 (% 47) kadın 185 hasta çalışmaya dahil edildi. Ortalama yaş 12.6 (dağılım 3-56) idi. Toplam 64 hastada Actinomiçes varlığı gösterildi.Sonuç: Actinomyces türleri bademcik dokusu florasında fırsatçı enfeksiyona neden olan bakterilerdir. Tonsiller Aktinomikoz kolonizasyonu yetişkinlerde ve büyük çocuklarda daha yaygındır.
  • [ X ]
    Öğe
    Trace Elements (Zn and Cu) and Oxidative Stress in Pediatric Patients with Persistent Allergic Rhinitis
    (2022) Günizi, Hüseyin; Savaş, Hasan Basri; Genç, Sibel
    Objective: To investigate the relationship between complaints and serum trace elements and oxidative stress levels in pediatric patients with allergic rhinitis (AR). Study design: Descriptive study. Place and duration of study: Department of Otolaryngorhinology, Medicine Faculty, Alanya Alaaddin Keykubat University, between May and September 2020. Methodology: Thirty-five patients diagnosed with AR in the pediatric age group and 35 healthy control groups were examined. The patients were evaluated according to the ARIA (Allergic rhinitis and its ımpact on asthma) guidelines. Blood samples were taken during the attack to measure serum Zn and Cu levels and oxidative stress levels from patients diagnosed with AR. Measurements of serum Zinc and Copper levels, and recently developed new generation oxidant-antioxidant balance markers were performed spectrophotometrically using a commercial kit.] Results: The mean ages of the study patients and healthy controls were 10.9 ± 4.7 and 10.5 ± 4.9 years, respectively. Female/Male ratio was 20 (57.1%)/15 (42.9%) in both groups. Zn level was lower in the patient group (p <0.05). Total thiol and native thiol values were higher in the control group (p <0.05). Statistically significant high disulfide values were found in allergic patients (p <0.05). Conclusion: Oxidative stress plays a role in the pathophysiology of allergic rhinitis, and thiol-disulfide hemostasis may be an indicator in allergic rhinitis. Key Words: Oxidative stress, Allergic rhinitis, Thiol, Disulfide, Cu, Zn.
  • [ X ]
    Öğe
    Upper airway obstruction and nocturnal enuresis in children: Why is it important?
    (2024) Kol, Arif; Günizi, Hüseyin; Genç, Şakir
    Objectives: Nocturnal enuresis (NE) is a common urological complaint among children. The most common cause of obstructive airway disease in children is enlarged tonsils and adenoids. Although the relationship between the presence of NE and sleep disorders is unclear, some studies show that enuresis improves after airway obstruction is resolved. We aimed to investigate the relationship between upper airway obstruction and NE in children. Methods: Between September 2020 and June 2021, 66 pediatric patients diagnosed with persistent NE were included in the study. A total of 57 healthy patients were included in the control group. The presence of snoring and apnea, the presence of Attention-Deficit/Hyperactivity Disorder (ADHD)/social adjustment disorder, academic achievement, and family members’ history of NE were asked through questionnaires filled out by the families. An upper airway examination was done with a flexible nasopharyngoscope. Results: The mean ages of the study patients and healthy controls were 8.32±2.1 and 8.18±2.3 years. The female/male ratio was (25/41) and (33/24), respectively. Of the case group, 62.1% were male, and 78.8% were under nine years old. The frequency of snoring/apnea in children with enuresis was 27.3%, while it was 19.3% in the control group (p=0.299). It was found that more enuresis developed in children with high BMI (p=0.044). Family history was higher in the NE group than in the control group, but it was not statistically significant (p=0.173). Conclusion: Nocturnal enuresis is commonly associated with obstructive sleep apnea. Upper airway obstruction, obesity, and male gender are important risk factors for NE.