Adaptive immune system in severe COVID-19 patients in the first week of illness: A pilot study

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dc.contributor.authorErsoy Dursun, Fadime
dc.contributor.authorÇağ, Yasemin
dc.contributor.authorİğneci, Ender
dc.contributor.authorIşık Gören, Burcu
dc.contributor.authorArslan, Ferhat
dc.contributor.authorAkarsu Ayazoğlu, Tülin
dc.contributor.authorIşman, Ferruh Kemal
dc.contributor.authorVahoboğlu, Mustafa Haluk
dc.date.accessioned2023-07-31T13:09:53Z
dc.date.available2023-07-31T13:09:53Z
dc.date.issued2023
dc.departmentALKÜ
dc.description.abstractIntroduction: The presentation of the course of COVID-19-related T-cell responses in the first week of the disease may be a more specific period for adaptive immune response assessment. This study aimed to clarify the relationship between changes in peripheral blood lymphocyte counts and death in patients with COVID-19 pneumonia. Methods: Thirty-three patients (14 females and 19 males) admitted for severe and desaturated COVID-19 pneumonia confirmed by polymerase chain reaction were included. Lymphocyte subsets and CD4+/CD8+ and CD16+/CD56+ rates were measured using flow cytometry from peripheral blood at admission and on the day of death or hospital discharge. Results: Twenty-eight patients survived and five died. On the day of admission, the CD4+ cell count was significantly higher and the saturation of O2 was significantly lower in the deceased patients compared to the survivors (P < 0.05). The CD16+/CD56+ rate was significantly lower on the day of death in the deceased patients than in discharge day for the survivors (P = 0.013). Conclusion: CD4+ lymphocyte percentages and O2 saturation in samples taken on the day of admission to the hospital and CD16+/CD56+ ratios taken at the time of discharge from the hospital were found to be associated with the mortality in patients with severe COVID-19.
dc.identifier.doi10.1556/1886.2022.00022
dc.identifier.endpage106en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage100en_US
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85148434163&origin=resultslist&sort=plf-f&src=s&nlo=&nlr=&nls=&sid=20c4fe371b9b908d4f7e419f791331ff&sot=aff&sdt=cl&cluster=scofreetoread%2c%22all%22%2ct&sl=72&s=AF-ID%28%22Alanya+Alaaddin+Keykubat+University%22+60198720%29+AND+SUBJAREA%28MEDI%29&relpos=17&citeCnt=0&searchTerm=
dc.identifier.urihttps://hdl.handle.net/20.500.12868/2333
dc.identifier.urihttps://akjournals.com/view/journals/1886/12/4/article-p100.xml
dc.identifier.volume12en_US
dc.indekslendigikaynakScopus
dc.language.isoen
dc.relation.ispartofEuropean Journal of Microbiology and Immunology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCOVID-19
dc.subjectCD4? T-cells
dc.subjectCD8? T-cells
dc.subjectLymphocyte subgroups
dc.titleAdaptive immune system in severe COVID-19 patients in the first week of illness: A pilot study
dc.typeArticle

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