Prognostic Effect of Psoas Muscle Index, a Parameter of Sarcopenia, in Solid Cancer Patients Receiving Immunotherapy
[ X ]
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objectives: In this study, our objective was to evaluate the prognostic feature of sarcopenia and prognostic labora- tory markers, defined by using PMI measurement in patients with kidney cancer and malignant melanoma, receiving immunotherapy. Methods: Diagnosed with and followed up for kidney cancer (RCC) and malignant melanoma (MM) and received Nivolumab immunotherapy in the Oncology Clinic, were retrospectively analyzed. Laboratory examinations and CT images used for staging in the diagnosis were retrospectively used for psoas muscle measurements. Results: We investigated the effect of pretreatment PMI on survival and response to treatment. For this purpose, 93 patients with malignant melanoma (n=45) and kidney cancer (n=48) were included in the study. Among female pa- tients with and without sarcopenia at baseline, median progression-free survival was 30.2 and 50.1 months (p=0.769), respectively, while in men, conversely, 54.8 and 34.3 months (p=0.307), respectively. Median overall survival was 31.0 and 51.7 months (p=0.763) in female patients with and without sarcopenia, respectively, and 62.9 and 52.4 months in males with and without sarcopenia (p=0.906). Conclusion: This result may suggest that sarcopenia has a negative effect on the immune response. It should be con- sidered that sarcopenia may affect the clinical outcomes of immunotherapy. Further studies are needed.
Açıklama
Anahtar Kelimeler
Sarcopenia, immunotherapy, solid cancer, PMI, metabolic index
Kaynak
Eurasian Journal of Medical Investigation
WoS Q Değeri
Scopus Q Değeri
Cilt
7
Sayı
4
