The relationship between neuroprotective activity and antigenotoxic and acetylcholinesterase inhibitory effects of Glaucium corniculatum extracts

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dc.contributor.authorKoçancı, Fatma Gonca
dc.contributor.authorHamamcıoğlu Buket
dc.contributor.authorAslım, Belma
dc.date.accessioned2022-09-12T10:28:05Z
dc.date.available2022-09-12T10:28:05Z
dc.date.issued2022
dc.departmentALKÜ, Meslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler Bölümü
dc.description.abstractThe purpose of this study was to investigate the relationship between the acetylcholinesterase (AChE) inhibitory and antigenotoxic effect with the neuroprotective activity of Glaucium corniculatum methanol and water extracts rich in rutin and quercetin flavonoids. Neuroprotective activity in terms of cell survival and development against oxidative damage was measured by MTT assay and microscopic analysis in H2 O2 -induced NGF-differentiated PC12 (dPC12) cells. QRT-PCR and western blot hybridization method was employed for the determination of AChE inhibition of the extracts in the same cell model, and the genotoxic and antigenotoxic effects were identified with Comet assay with human lymphocytes. H2 O2 -induced vitality loss in dPC12 cells was inhibited in pre-treated cells with these plant extracts. Moreover, extracts stimulated neurite formation and prevented the oxidative stress-induced reduction in neurite growth. In general, it was determined that G. corniculatum methanol extract containing higher amounts of rutin and quercetin was more effective than water extract in terms of AChE inhibitory, antigenotoxic and also neuroprotective effect. In this study, it was shown for the first time that both AChE inhibitory and antigenotoxic effects of G. corniculatum may be effective in neuroprotection and it’s protective and therapeutic effects against neurodegeneration may be related to the flavonoid content.
dc.identifier.doihttp://dx.doi.org/10.1590/s2175-97902022e19472
dc.identifier.endpage14en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12868/1540
dc.identifier.urihttps://www.scielo.br/j/bjps/a/5MCfzfYzzFzdVfggwpBNkDr/?lang=en
dc.identifier.volume58en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.relation.ispartofBrazilian Journal of Pharmaceutical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGlaucium corniculatum
dc.subjectNeuroprotection
dc.subjectAntigenotoxicity
dc.subjectAChE inhibition
dc.subjectFlavonoi
dc.titleThe relationship between neuroprotective activity and antigenotoxic and acetylcholinesterase inhibitory effects of Glaucium corniculatum extracts
dc.typeArticle

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