LOW LEVEL LASER THERAPY REDUCES ANTICANCER POTENTIAL OF COLLOIDAL SILVER THROUGH TRPV1 CHANNELS SHORT TITLE: LLLT REDUCES ANTICANCER POTENTIAL OF COLLOIDAL SILVER

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dc.contributor.authorÖvey, İshak Suat
dc.contributor.authorGüler, Yilmaz
dc.contributor.authorCelik, O.
dc.date.accessioned2026-01-24T12:20:43Z
dc.date.available2026-01-24T12:20:43Z
dc.date.issued2023
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractBackground: Recently there are studies which particularly investigated efficiency of silver on neoplastic diseases. and many other diseases. Low level laser therapy (LLLT) has been shown to modulate biological processes and there are many studies that investigate the effect of LLLT, which is used in the treatment of cancers currently. Methods: Breast (MCF7) and colon (Caco-2) cells were cultured and cells were divided into seven main groups. Cells were incubated with colloidal silver for 24 hrs. Colloidal silver and LLLT exposure separately and together performed on MCF7 and Caco-2 cell cultures. The effects of colloidal silver and LLLT were invastigated on mitochondrial pathways of apoptosis. Results: It was found that the levels of apoptosis in colloidal silver group were significantly increased in both cancer cells compared to control group. In both cancer cells, transient receptor protein vanilloid 1 (TRPV1) channel stimulator Cpcn administration resulted in significantly increased apoptosis levels compared to the control group, in colloidal silver + 650nm (LLLT) group the apopitosis level significantly reduced compared to colloidal silver-only group. Conclusions: It has been shown that colloidal silver significantly increases apoptosis in breast and colon cancer cells, however LLLT administration decreases apoptosis in both wavelength and suppressed apoptotic effect of colloidal silver significantly on these cells. © 2023 Interciencia Association. All rights reserved.
dc.identifier.doi10.59671/hje0t
dc.identifier.endpage33
dc.identifier.issn0378-1844
dc.identifier.issue5
dc.identifier.scopus2-s2.0-85165982096
dc.identifier.scopusqualityQ3
dc.identifier.startpage14
dc.identifier.urihttps://doi.org/10.59671/hje0t
dc.identifier.urihttps://hdl.handle.net/20.500.12868/4536
dc.identifier.volume48
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherInterciencia Association
dc.relation.ispartofInterciencia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_Scopus_20260121
dc.subjectbreast cancer
dc.subjectColloidal silver
dc.subjectcolon cancer
dc.subjectLow Level Laser
dc.subjectTRPV1
dc.titleLOW LEVEL LASER THERAPY REDUCES ANTICANCER POTENTIAL OF COLLOIDAL SILVER THROUGH TRPV1 CHANNELS SHORT TITLE: LLLT REDUCES ANTICANCER POTENTIAL OF COLLOIDAL SILVER
dc.typeArticle

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