The Relationship of Learning and Memory Disfunction with NEURL1 and RGS14 Genes in Patients with Autism Spectrum Disorders

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dc.contributor.authorEciroğlu, Hamiyet
dc.contributor.authorŞener, Elif Funda
dc.contributor.authorÖztop, Didem Behice
dc.contributor.authorÖzmen, Sevgi
dc.contributor.authorKaan, Dilek
dc.contributor.authorYusuf, Özkul
dc.date.accessioned2022-10-03T11:08:35Z
dc.date.available2022-10-03T11:08:35Z
dc.date.issued2022
dc.departmentALKÜ, Meslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler Bölümü
dc.description.abstractAim: We aimed to evaluate the relationship between learning-memory difficulties and NEURL1 and RGS14 genes in patients with autism spectrum disorders (ASD). Method: Forty children with ASD (20 ASD, 20 high functioning autism (HFA)) and 20 healthy controls were enrolled in this study. NEURL1 and RGS14 gene expressions in blood samples of volunteers were assessed by quantitative Real-Time PCR (qRTPCR). The clinical and demographical findings in patients were determined and examined in relation to the gene expressions. Results: According to our findings, NEURL1 gene expression was decreased in both patient groups compared to the control (p<0.05). No significant difference between the groups in terms of the RGS14 gene (p>0.05). A statistically significant correlation was found between learning and memory difficulties and RGS14 gene expression in HFA patients (p=0.045). A positive correlation was observed between NEURL1 and RGS14 gene expressions of ASD patients (p=0.032, r=0,59). Conclusion: In this study, we showed that the NEURL1 gene may affect learning and memory difficulties in ASD patients. Nonetheless, we recommend that both genes be studied with more patients and preferably with brain tissues. These genes were evaluated for the first time in a clinical study on autism, and we believe that they will contribute to the literature in this respect.
dc.identifier.doi10.30565/medalanya.1136820
dc.identifier.endpage213en_US
dc.identifier.issue2en_US
dc.identifier.startpage207en_US
dc.identifier.urihttps://dergipark.org.tr/tr/download/article-file/2511272
dc.identifier.urihttps://hdl.handle.net/20.500.12868/1774
dc.identifier.volume6en_US
dc.language.isoen
dc.relation.ispartofActa Medica Alanya
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAutism
dc.subjectNeuralized1
dc.subjectRGS14
dc.subjectLearning
dc.subjectMemory
dc.titleThe Relationship of Learning and Memory Disfunction with NEURL1 and RGS14 Genes in Patients with Autism Spectrum Disorders
dc.typeArticle

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2022 - Cilt 6 - Sayı 2