Investigation of the protective effects of geraniol on cyclophosphamide-induced hepatotoxicity in rats

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dc.contributor.authorCanbaz, Halime Tuba
dc.contributor.authorKalkan, Serpil
dc.contributor.authorKocabas, Rahim
dc.contributor.authorSozen, Mehmet Enes
dc.contributor.authorCuce, Gokhan
dc.date.accessioned2026-01-24T12:26:47Z
dc.date.available2026-01-24T12:26:47Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractThis study aimed to investigate the efficacy of geraniol (Ge) on improving cyclophosphamide (CP)-induced hepatotoxicity in rats. A total of 42 rats in 6 groups, group I (control); group II (CP at 20 mg/kg); group III (CP at 20 mg/kg + Ge at 100 mg/kg); group IV (CP at 20 mg/kg + Ge at 200 mg/kg); group V (Ge at 100 mg/kg); and group VI (Ge at 200 mg/kg), were used. Ge was administered orally via gavage daily for 14 days. Intraperitoneal CP was administered from day 8 to 14. Blood serums were analysed for alanine aminotransferase (ALT), aspartate aminotransferase (AST), total antioxidant status (TAS), and total oxidant status (TOS) over a 14-day period. Liver sections were stained using hematoxylin and eosin (H&E). NF kappa B expression was assessed using immunohistochemistry. Bax-Bcl immunofluorescence was employed to identify apoptosis, whereas TUNEL was utilised to detect DNA fragmentation. Group III and group IV exhibited significantly decreased histopathological scores, NF kappa B expression, and DNA breaks compared to group II. The OSI and AST levels were significantly reduced in group IV compared to group II. The current investigation indicates that Ge possesses anti-inflammatory and antioxidant effects on CP-induced liver damage.
dc.description.sponsorshipNecmettin Erbakan University Scientific Research Projects Coordinatorship [171418005]
dc.description.sponsorshipThis study was supported by Necmettin Erbakan University Scientific Research Projects Coordinatorship with decision number 171418005.
dc.identifier.doi10.56042/ijeb.v63i09.18020
dc.identifier.endpage745
dc.identifier.issn0019-5189
dc.identifier.issn0975-1009
dc.identifier.issue9
dc.identifier.startpage738
dc.identifier.urihttps://doi.org/10.56042/ijeb.v63i09.18020
dc.identifier.urihttps://hdl.handle.net/20.500.12868/4928
dc.identifier.volume63
dc.identifier.wosWOS:001648029100003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherNatl Inst Science Communication-Niscair
dc.relation.ispartofIndian Journal of Experimental Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectChemoprevention
dc.subjectAntioxidants
dc.subjectHistopathology
dc.subjectLiver
dc.subjectApoptosis
dc.titleInvestigation of the protective effects of geraniol on cyclophosphamide-induced hepatotoxicity in rats
dc.typeArticle

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