Serum soluble Fas-ligand levels and flow-mediated vasodilation in patients undergoing peritoneal dialysis

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dc.contributor.authorHuddam, Bülent
dc.contributor.authorAzak, Alper
dc.contributor.authorKarakuş, Volkan
dc.contributor.authorAlp, Alper
dc.contributor.authorGenek, Dilek Gibyeli
dc.contributor.authorKoçak, Meral Gülay Kadıoğlu
dc.contributor.authorDere, Yelda
dc.contributor.authorSoysal, Dilek Ersil
dc.contributor.authorDuranay, Murat
dc.date.accessioned2023-10-09T06:58:32Z
dc.date.available2023-10-09T06:58:32Z
dc.date.issued2022
dc.departmentALKÜ
dc.description.abstractFlow-mediated vasodilation (FMD) has been demonstrated to be a useful, non-invasive tool for the detection ofendothelialdysfunction in atherosclerotic cardiovascular disease, the leading cause of mortality in end-stage kidney disease. The Fas/Fas ligand system of apoptosis resulting from activation of the caspase cascade- contributes to the pathophysiology of atherosclerosis. This ‘apoptotic’ system plays a central role in immune homeostasis. Vascular endothelial cells and inflammatory cells are the main resources of the Fas ligand. In this study, we aimed to investigate the role of soluble Fas ligand (sFasL) as a marker of FMD in peritoneal dialysis (PD) patients. Methods. A total of 43 patients undergoing maintenance PD and 40 healthy donors were enrolled in this cross-sectional observational study. Demographics, anthropometric measurements and clinical examinations were obtained. Endothelial function was evaluated by FMD of the brachial artery with high-resolution ultrasonography. Serum sFasL concentrations were measured with an enzyme-linked immunosorbent assay kit. Results. The enrolled partisipants were devited on 2 groups: PD patients who had been treated at least 12 weeks (group 1; mean age 41±14 years, M/F: 22/21) and gender matched 40 healthy controls (group 2; mean age 50±12 years, M/F: 19/20). The forearm FMD and serum sFasL levels were significantly lower in PD patients (3.95±2.01 vs 8.83 ± 6.17; p<0.001 and 54 ± 24 vs 73 ± 30; p=0.001). Forearm FMD was correlated with sFasL (r=0.289; p=0.008), age, BMI and uric acid (r= 0,32; p=0.003, respectively), hemoglobin (r= 0,293; p=0.007), calcium (r= 0,26; p=0.016), phosphate (r=- 0,250; p=0.023), magnesium (r= 0,255; p=0.020), 24 h SBP (r=- 0,257; p=0.019), creatinine and iPTH (r=- 0.50 and r=- 0,45; p[removed]
dc.identifier.doi10.31450/ukrjnd.2(74).2022.04
dc.identifier.endpage32en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage25en_US
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85141104361&origin=resultslist&sort=plf-f&src=s&nlo=&nlr=&nls=&sid=20c4fe371b9b908d4f7e419f791331ff&sot=aff&sdt=cl&cluster=scofreetoread%2c%22all%22%2ct&sl=72&s=AF-ID%28%22Alanya+Alaaddin+Keykubat+University%22+60198720%29+AND+SUBJAREA%28MEDI%29&relpos=73&citeCnt=0&searchTerm=
dc.identifier.urihttps://hdl.handle.net/20.500.12868/2398
dc.identifier.urihttps://ukrjnd.com.ua/index.php/journal/article/view/611
dc.indekslendigikaynakScopus
dc.language.isoen
dc.relation.ispartofUkrainian Journal of Nephrology and Dialysis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPeritoneal dialysis
dc.subjectFlow-mediated vasodilation
dc.subjectSoluble Fas-ligand
dc.subjectEndothelial dysfunction
dc.titleSerum soluble Fas-ligand levels and flow-mediated vasodilation in patients undergoing peritoneal dialysis
dc.title.alternative[???????????? ?????????? Fas-??????? ? ????????? ?? ???????????????????? ????????????? ? ?????????, ??? ????????? ??????? ??????????????? ???????]
dc.typeArticle

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