The diagnostic value of parathormone washout in Tc-99m MIBI negative primary hyperparathyroidism cases
| dc.contributor.author | Korkmaz, Hakan | |
| dc.date.accessioned | 2022-09-26T11:07:29Z | |
| dc.date.available | 2022-09-26T11:07:29Z | |
| dc.date.issued | 2021 | |
| dc.department | ALKÜ | |
| dc.description.abstract | Aim: To determine the sensitivity and positive predictive value (PPV) of the measurement of parathormone (PTH) in fine needle aspiration (FNA) washout fluid, in the preoperative localization of hyperfunctional parathyroid lesions. Methods: Medical records of patients diagnosed with primary hyperparathyroidism (PHPT) in our clinic between 2016-2020 were retrospectively evaluated. Thirty-six patients with PHPT who underwent preoperative FNA-PTH washout procedure were included in the study. FNA-PTH washout was only performed in patients with negative technetium-99m methoxy isobutyl isonitrile / single photon emission computed tomography (Tc-99m MIBI/SPECT) imaging. It was accepted to be higher than plasma PTH level as positive cut-off value for PTH washout in determining parathyroid lesions. Sensitivity, PPV, false positive, false negative and diagnostic accuracy values of PTH washout were calculated. Results: PTH washout was false positive in 2 cases, false negative in 1 case and true positive in 33 cases. In the discrimination of true parathyroid lesions, the sensitivity of PTH washout was calculated as 97.05%, PPV 94.29% and diagnostic accuracy 91.67%. PTH washout levels correlated positively with plasma PTH and parathyroid lesion volüme (respectively, r=0.347, p=0.041 ve r=0.356, p=0.036). All patients tolerated the FNA-PTH flushing procedure well and no complications developed afterwards. Conclusion: The FNA-PTH washout is a safe and useful method to localise parathyroid lesions in PHPT patients with negative Tc-99m MIBI/SPECT imaging. | |
| dc.identifier.doi | https://doi.org/10.30565/medalanya.853038 | |
| dc.identifier.endpage | 65 | en_US |
| dc.identifier.issue | 1 | en_US |
| dc.identifier.startpage | 61 | en_US |
| dc.identifier.uri | https://hdl.handle.net/20.500.12868/1697 | |
| dc.identifier.volume | 5 | en_US |
| dc.language.iso | en | |
| dc.relation.ispartof | Acta Medica Alanya | |
| dc.relation.publicationcategory | Makale - Ulusal Hakemli Dergi - Başka Kurum Yazarı | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | Fine needle aspiration | |
| dc.subject | MIBI/SPECT negative | |
| dc.subject | Primary hyperparathyroidism | |
| dc.subject | Washout | |
| dc.title | The diagnostic value of parathormone washout in Tc-99m MIBI negative primary hyperparathyroidism cases | |
| dc.type | Article |
