The Relationship Between Odontogenic Cyst and P53 Codon 72 And P53 Codon 175 Variants in Turkish Patients

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dc.contributor.authorTumer, Mehmet Kemal
dc.contributor.authorKeskin, Adem
dc.contributor.authorAci, Recai
dc.contributor.authorYigit, Serbulent
dc.date.accessioned2026-01-24T12:01:06Z
dc.date.available2026-01-24T12:01:06Z
dc.date.issued2023
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractObjective: Odontogenic cysts that cause bone destruction can exhibit various types of metaplasia. Inherited genetic variants in codons 72 and 175, the hotspot codons of p53, known as the guardian of the genome, can cause a wide variety of cancers. We aimed to investigate the effects of the p53 codon 72 and p53 codon 175 variants on odontogenic cyst formation. Methods: This research encompassed 71 individuals with odontogenic cysts and 90 without any conditions as a control group. After DNA was extracting, the p53 codon 72 was detected using PCR techniques, while p53 codon 175 was identified through allele-specific amplification-PCR. Results: The presence of the p53 codon 72 GG genotype and its G allele was less frequent in the group with odontogenic cysts compared to the healthy participants. Conversely, the C allele was found more often in the cyst-afflicted group. For the p53 codon 175, the AA genotype and A allele were more common in the affected group, while the G allele was more predominant in the control group. Conclusion: The p53 codon 175 AA genotype and A allele, p53 codon 72 C allele, and p53 codon 72/codon 175 CCAA combined genotype may be associated with odontagenic cyst formation. Individuals with this allele and genotype can be considered at risk for odontagenic cyst formation.
dc.identifier.doi10.58600/eurjther1911
dc.identifier.endpage797
dc.identifier.issn2564-7784
dc.identifier.issn2564-7040
dc.identifier.issue4
dc.identifier.startpage790
dc.identifier.trdizinid1221451
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1221451
dc.identifier.urihttps://doi.org/10.58600/eurjther1911
dc.identifier.urihttps://hdl.handle.net/20.500.12868/4000
dc.identifier.volume29
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofEuropean Journal of Therapeutics
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR-Dizin_20260121
dc.subjectGene
dc.subjectMetaplasia
dc.subjectOdontogenic cysts
dc.titleThe Relationship Between Odontogenic Cyst and P53 Codon 72 And P53 Codon 175 Variants in Turkish Patients
dc.typeArticle

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