Evaluation of the Effect of Thymol on the Cytotoxicity of Cetuximab in Lung Cancer Cells

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dc.contributor.authorErdogan, Ayse
dc.contributor.authorHaznedar, Ekin
dc.contributor.authorBaşer, Mehmet
dc.date.accessioned2026-01-24T12:01:01Z
dc.date.available2026-01-24T12:01:01Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractThe treatment of lung cancer continues to be a significant challenge for many oncologists and their patients. Treatment using epidermal growth factor receptor inhibitors is connected to a positive outcome. Cetuximab, a chimeric monoclonal antibody targeting the epidermal growth factor receptor (EGFR), in conjunction with monoterpene phenol thymol, is recommended for the treatment of lung cancer. While a mild acne-like skin rash is quite frequent in patients using cetuximab, a severe rash is rare. The goal of the current study was to assess whether thymol could enhance the anticancer effectiveness of cetuximab in A-549, non-small cell lung cancer (NSCLC) cell line. We found that the combination of cetuximab and thymol synergistically suppressed cell proliferation by inducing membrane damaging, oxidative stress, and apoptosis in A-549 cells. Taken together, our results indicate that the combination of thymol and cetuximab could improve anticancer responses and may notably enhance treatment outcomes in NSCLC.
dc.identifier.doi10.31594/commagene.1644311
dc.identifier.endpage48
dc.identifier.issn2602-456X
dc.identifier.issue1
dc.identifier.startpage42
dc.identifier.trdizinid1323744
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1323744
dc.identifier.urihttps://doi.org/10.31594/commagene.1644311
dc.identifier.urihttps://hdl.handle.net/20.500.12868/3920
dc.identifier.volume9
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofCommagene Journal of Biology
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR-Dizin_20260121
dc.subjectApoptosis
dc.subjectlung cancer
dc.subjectCetuximab
dc.subjectcarvacrol
dc.subjectsynergistic anticancer effect
dc.titleEvaluation of the Effect of Thymol on the Cytotoxicity of Cetuximab in Lung Cancer Cells
dc.typeArticle

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