The evaluation of sperm DNA damage in patients with different varicocele grades

Basit Öğe Kaydı
dc.contributor.authorGöktepe, Özge
dc.contributor.authorCantürk Tan, Fazile
dc.contributor.authorNarin, Figen
dc.contributor.authorYakan, Birkan
dc.date.accessioned2022-09-30T07:19:53Z
dc.date.available2022-09-30T07:19:53Z
dc.date.issued2021
dc.departmentALKÜ
dc.description.abstractAim: Varicocele, abnormal dilatation of pampiniform venous plexus, is classified into three groups: 1st, 2nd and 3rd grade. The aim of our research is to show the differences among the three different varicocele grades based on the results of their sperm DNA damage and blood biochemical parameters. Methods: We examined 30 patients which were classified into three groups: Group 1 (healthy), Group 2 (grades 1 and 2) and Group 3 (grade 3). The semen samples were examined in terms of DNA damage via comet assay. The blood samples were assessed using catalase (CAT), superoxide dismutase (SOD) enzyme activities and malondialdehyde (MDA) levels. Results: According to the comet findings, Group 2 and Group 3 parameters were significantly higher than Group 1 (p < 0.01). In the biochemical findings, we observed decreased CAT and SOD activities and an increased MDA level for Group 2 and Group 3. In our research, we showed that grades 1 and 2 had significant DNA damage in terms of infertility as much as grade 3. Conclusion: The results we derived indicate that the detection of DNA damage could be used as a predictor of infertility alongside routine semen and morphological analysis.
dc.identifier.doi10.30565/medalanya.849413:
dc.identifier.endpage233en_US
dc.identifier.issue2en_US
dc.identifier.startpage226en_US
dc.identifier.urihttps://dergipark.org.tr/tr/download/article-file/1476005
dc.identifier.urihttps://hdl.handle.net/20.500.12868/1725
dc.identifier.volume5en_US
dc.language.isoen
dc.relation.ispartofActa Medica Alanya
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Başka Kurum Yazarı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectVaricocele
dc.subjectInfertility
dc.subjectSpermatozoa
dc.subjectDNA damage
dc.titleThe evaluation of sperm DNA damage in patients with different varicocele grades
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
10.30565-medalanya.849413-1476005.pdf
Boyut:
935.26 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

2021 - Cilt 5 - Sayı 3