Protective effect of Lumbricus rubellus Hoffmeister extract in experimental renal ischemia/reperfusion injury in the nephrectomy rats

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dc.authorid0000-0002-1120-1874
dc.contributor.authorOz, Semih
dc.contributor.authorYildiz, Fatma
dc.contributor.authorKabay, Sahin
dc.contributor.authorSenturk, Hakan
dc.contributor.authorDonmez, Dilek Burukoglu
dc.contributor.authorOzbayer, Cansu
dc.contributor.authorUstuner, Mehmet Cengiz
dc.date.accessioned2026-01-24T12:26:47Z
dc.date.available2026-01-24T12:26:47Z
dc.date.issued2023
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractAcute kidney injury (AKI), an immediate loss of renal function, leads to high mortality, and ischemia-reperfusion (I/R) injury is considered as one of the main causes of AKI. Inflammation and oxidative stress are known to play an important role in AKI. On the other hand, the earthworm extract, used in traditional medicine, is known to possess various biological and pharmacological activities viz. antiapoptotic, anticoagulative, fibrinolytic, anti-inflammatory, antioxidative stress, peripheral nerve regeneration, bone regeneration and wound healing. Hence, in this study, we investigated the protective effect of the earthworm Lumbricus rubellus Hoffmeister extract (LE) after nephrectomy, against oxidative stress occurring during renal ischemia/reperfusion (I/R) injury. A total of 10-12 weeks old Sprague Dawley male rats were divided into five groups (n=8). Group I (control), Group II (I/R), Group III (I/R + 10 mg/kg LE), Group IV (I/R + 20 mg/kg LE) and Group V (I/R + 40 mg/kg LE). All rats except in Gr. I were applied ischemia for 45 min and reperfusion for 24 h. At the end of the experiment, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) enzyme activities and malondialdehyde (MDA) levels were evaluated. In addition, kidney tissues were evaluated histologically. In results, the MDA and GPx level of the I/R group were found to be significantly higher than the control and LE groups. SOD activity of the control group did not differ when compared to LE groups and CAT levels were not significantly different between all groups. In addition, in Gr. III-V we observed nearly normal renal cortex and renal tubules. The present study, thus demonstrates that the extract of L. rubellus prevents renal I/R injury and induced biochemical and histological changes in the renal tissues in rats.
dc.identifier.doi10.56042/ijeb.v61i12.1532
dc.identifier.endpage916
dc.identifier.issn0019-5189
dc.identifier.issn0975-1009
dc.identifier.issue12
dc.identifier.startpage911
dc.identifier.urihttps://doi.org/10.56042/ijeb.v61i12.1532
dc.identifier.urihttps://hdl.handle.net/20.500.12868/4927
dc.identifier.volume61
dc.identifier.wosWOS:001112537100008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherNatl Inst Science Communication-Niscair
dc.relation.ispartofIndian Journal of Experimental Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectAntioxidants
dc.subjectEarthworm extract
dc.subjectKidney
dc.subjectReactive oxygen species (ROS)
dc.titleProtective effect of Lumbricus rubellus Hoffmeister extract in experimental renal ischemia/reperfusion injury in the nephrectomy rats
dc.typeArticle

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