Can Carpobrotus edulis, heal incisional and excisional wounds on the skin?

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dc.contributor.authorGünal, Mehmet Yalçın
dc.contributor.authorAyla, S.
dc.contributor.authorÇağlayan, B.
dc.contributor.authorBeker, M.C.
dc.contributor.authorBedri, N.
dc.contributor.authorAslan, I.
dc.contributor.authorÖzdemir, E.M.
dc.contributor.authorKılıç, E.
dc.contributor.authorYeşilada, E.
dc.date.accessioned2022-09-22T06:19:00Z
dc.date.available2022-09-22T06:19:00Z
dc.date.issued2021
dc.departmentALKÜ, Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractOBJECTIVES: This study aimed to investigate the wound healing activity of liposomal Carpobrotus edulis powder extract (CEPE) formulation on incisional and excisional wounds in rat. BACKGROUND: In the event of any damage, the damaged tissue undergoes a process of regenerating itself, which is called wound healing. METHODS: Centella asiatica extract (CAE) was used as the reference molecule in the study. The wound healing process was tested by using the excisional and incisional wound model. On the 12th day of the study, maximum stress, stress, % of elongation values were evaluated in the incisional wound. Also; histological parameters and macroscopic photographic analyses were evaluated in the excisional wound. RESULTS: In the photo evaluations, the improvement was more prominent in both CAE and CEPE groups than in the control group. Histological evaluation showed that CEPE group had significant wound healing activity compared to the control and CAE groups. Axial tensile-elongation experiments in incisional wound tissue show that there was no significant difference between CAE and CEPE groups. CONCLUSION: Liposomal formulations of C.edulis extract were found to have positive effects on the healing process, both on excisional and incisional wound tissues (Tab. 2, Fig. 3, Ref. 30). Text in PDF www.elis.sk
dc.identifier.doi10.4149/BLL_2021_147
dc.identifier.endpage917en_US
dc.identifier.issue12en_US
dc.identifier.startpage912en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12868/1649
dc.identifier.urihttps://www.elis.sk/download_file.php?product_id=7493&session_id=kgfmj5dg9g8j1s7j7rhsags313
dc.identifier.volume122en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCarpobrotus edulis
dc.subjectLiposome
dc.subjectIncisional wound
dc.subjectExcisional wound
dc.subjectAxial tensile
dc.subjectElongation tests
dc.titleCan Carpobrotus edulis, heal incisional and excisional wounds on the skin?
dc.typeArticle

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