The differentiation of metastatic mediastinal lymph nodes From benign hypermetabolic lesions

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dc.contributor.authorBulut, Sertan
dc.contributor.authorÇelik, Deniz
dc.contributor.authorKaramanlı, Harun
dc.contributor.authorAktaş, Zafer
dc.contributor.authorÖzmen, Özlem
dc.contributor.authorErtürk, Hakan
dc.contributor.authorGürçay, Nesrin
dc.contributor.authorBiber, Çiğdem
dc.date.accessioned2022-09-12T10:26:28Z
dc.date.available2022-09-12T10:26:28Z
dc.date.issued2022
dc.departmentALKÜ, Fakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractBackground Anthracosis may cause a positron emission tomography/computed tomography (PET/CT) false positivity in mediastinal and hilar lymph nodes. We aimed to evaluate the radiological features and the maximum standardized uptake values (SUVmax) of the mediastinal lymph nodes with anthracosis or squamous cell lung cancer metastasized. Methodology Patients diagnosed with anthracosis or squamous cell lung cancer with endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) between January 1, 2015, and November 15, 2020, in a tertiary hospital were enrolled. The squamous cell subtype of lung cancer was selected due to its association with tobacco use, biomass, and air pollution. Anthracosis may occur due to the same etiologic reasons. Results A total of 190 patients met the study enrollment criteria, of which 86 were diagnosed with anthracosis and 33 with squamous cell lung cancer lymph metastasis. Median values for short axis, long axis, SUVmax, shape features, and presence of calcification were found significantly different between the groups. In receiver operating characteristic (ROC) analysis, the SUVmax cut-off value was calculated as 6.61. With this cutoff value, the negative predictive value (NPV) was 92.5% and the positive predictive value (PPV) was 54% for differentiating anthracosis and malignant lymph nodes metastasis. Conclusions We conclude that the evaluation of the shape and metabolic activities of the anthracotic lymph nodes detected by PET/CT together with EBUS-TBNA granted a more accurate staging of the patients and more cancer patients will benefit from surgical treatment.
dc.identifier.doiDOI: 10.7759/cureus.24884
dc.identifier.endpage12en_US
dc.identifier.issue5en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12868/1526
dc.identifier.urihttps://www.cureus.com/articles/94626-the-differentiation-of-metastatic-mediastinal-lymph-nodes-from-benign-hypermetabolic-lesions#!/
dc.identifier.volume14en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.relation.ispartofCureus Journal of Medical Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectsquamous cell lung cancer
dc.subjectendobronchial ultrasound-guided transbronchial needle aspiration
dc.subjectquamous cell lung cancer lymph metastasis
dc.subjectebus-tbna
dc.subjectsuvmax
dc.subjectpet/ct
dc.subjectsquamous cell lung cancer metastasized lymph nodes
dc.subjectanthracosis
dc.titleThe differentiation of metastatic mediastinal lymph nodes From benign hypermetabolic lesions
dc.typeArticle

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