Can Mecsina Hemostopper, which has a Cytotoxic Effect on Mcf-7 Cells, be Considered an Anticarcinogenic Agent due to its Immunological Properties?

Basit Öğe Kaydı
dc.contributor.authorCicek, Mustafa
dc.contributor.authorTumer, Mehmet Kemal
dc.contributor.authorTurgut, Alpgiray
dc.date.accessioned2026-01-24T12:01:19Z
dc.date.available2026-01-24T12:01:19Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractAim: Mecsina is used as a hemostatic agent such as Ankaferd and Tranexamic acid. To struggle with breast cancer, which is a serious public health issue, new, effective, and less toxic therapeutic agents are needed. Hence, it is aimed to compare and evaluate the effects of Mecsina and Ankaferd, both of which contain natural biomolecules in their structure, and synthetic Tranexamic acid on MCF-7 cells. Material and Method: For this study, MCF-7 immortalized cell lines were commercially purchased. The cells, 5000 cells per flask for each different dose group, were distributed to the 9 groups (mecsina 1:1, 1:2, 1:10, 1:50, 1:100, 1:200, 1:500, distilled water administered negative and control without any administration). Cytotoxicity, ELISA cytokine levels were evaluated, and flow cytometric analyzes were performed for each group using the XTT analysis method, after 24 hours of incubation. Results: A significant difference was observed between different doses of drug administration groups of Mecsina Hemostopper hemostatic agent in MCF-7 cells (p<0.001). Besides, cytokine levels were found to be significantly higher than those of other possible therapeutic agents. Conclusion: Mecsina Hemostopper has been found to have anti-tumoral activity in MCF-7 cancer cell lines by producing a hemostatic effect.
dc.identifier.doi10.37990/medr.1394291
dc.identifier.endpage26
dc.identifier.issn2687-4555
dc.identifier.issue1
dc.identifier.startpage20
dc.identifier.trdizinid1260012
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1260012
dc.identifier.urihttps://doi.org/10.37990/medr.1394291
dc.identifier.urihttps://hdl.handle.net/20.500.12868/4205
dc.identifier.volume6
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofMedical records-international medical journal (Online)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR-Dizin_20260121
dc.subjectMCF-7
dc.subjectflow cytometry
dc.subjectcytotoxicity
dc.subjectCD4+
dc.subjectCD8+
dc.subjectmecsina
dc.titleCan Mecsina Hemostopper, which has a Cytotoxic Effect on Mcf-7 Cells, be Considered an Anticarcinogenic Agent due to its Immunological Properties?
dc.typeArticle

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu