The Vitamin D Receptor Bsm1 Variant is not Associated With Temporomandibular Disorder With or Without Bruxism

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dc.contributor.authorYildiz, Serkan
dc.contributor.authorYigit, Serbulent
dc.contributor.authorNursal, Ayse Feyda
dc.contributor.authorKarakus, Nevin
dc.contributor.authorTumer, Mehmet Kemal
dc.date.accessioned2026-01-24T12:00:53Z
dc.date.available2026-01-24T12:00:53Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractBackground: Temporomandibular joint disorder (TMD), a set of conditions that affect the temporomandibular joint and related structures, is frequently linked to bruxism. The vitamin D receptor (VDR) affects calcium absorption, bone remodeling, and mineralization rate. The goal of this study was to evaluate the role of the VDR Bsm1 (rs1544410) variant in the susceptibility to bruxism in TMD. Method: A total of 321 people [221 TMD patients (135 with bruxism and 86 without bruxism) and 100 healthy controls] were included in the study. The VDR Bsm variant was genotyped using the PCR-RFLP method. Results: We found no significant difference between the all-TMD patient group and the control group regarding the VDR Bsm1 genotype and allele distribution (p>0.05). There was no deviation from HWE for the VDR variant in groups. There was no relationship between pain characteristics and VDR Bsml genotype distribution in patients with bruxism. Conclusions: Our results support the conclusion that the VDR Bsm1 variant is not a risk factor for the development of bruxism in TMD. The effect of the VDR Bsml variant on the risk of bruxism in TMD should be investigated in studies involving larger populations and other ethnicities.
dc.identifier.doi10.54617/adoklinikbilimler.1318039
dc.identifier.endpage106
dc.identifier.issn1307-3540
dc.identifier.issue1
dc.identifier.startpage100
dc.identifier.trdizinid1225167
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1225167
dc.identifier.urihttps://doi.org/10.54617/adoklinikbilimler.1318039
dc.identifier.urihttps://hdl.handle.net/20.500.12868/3801
dc.identifier.volume13
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofADO Klinik Bilimler Dergisi (online)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR-Dizin_20260121
dc.subjectPCR-RFLP
dc.subjectBruxism
dc.subjectVariant
dc.subjectTemporomandibular disorder
dc.subjectVitamin D receptor
dc.titleThe Vitamin D Receptor Bsm1 Variant is not Associated With Temporomandibular Disorder With or Without Bruxism
dc.typeArticle

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