Chemical Composition and Neurotherapeutic Potential of Glaucium corniculatum Extracts

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dc.authorid0000-0002-7248-7933
dc.contributor.authorKocanci, Fatma Gonca
dc.contributor.authorAslim, Belma
dc.date.accessioned2026-01-24T12:26:40Z
dc.date.available2026-01-24T12:26:40Z
dc.date.issued2021
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractBackground: The discovery of natural agents that suppress neural apoptosis is of strategic importance for the treatment of neurodegenerative diseases. Glaucium corniculatum has been used as a traditional medicine because of its memory-enhancing and neuroprotective properties. However, there has not been a study about this plant's apoptosis suppressive properties until now. Objectives: The present study examines the possible suppressive effects on apoptosis of three different G. corniculatum extracts (chloroform, methanol, and water) in neuronal-differentiated PC12 (dPC12) cells induced by hydrogen peroxide (H2O2) and presents the first association of compound content differences in extracts with the suppressive property. Materials and Methods: The chemical composition of these extracts was analyzed by Fourier transform infrared spectroscopy (FTIR) and gas chromatography-mass spectroscopy. The changes caused by the extracts in apoptotic markers were examined by real-time quantitative polymerase chain reaction and Western blot. Results: Extracts contained alkaloid, fatty acid, alcohol, alkane hydrocarbon, ester, ether, alkane, alkene, aliphatic, aromatic, and phenolic compounds with different relative proportions. In all the three extracts, the major compound was allocriptopine. Oleamide and 2-monopalmitin were the major fatty acids, respectively, identified in water and methanol extracts. Extracts were suppressed H2O2-induced apoptosis via decreasing the expression of Bax, Caspase-3 and -9, while increasing Bcl-2, in a concentration-dependent manner. The water extract showed the highest apoptosis suppression while methanol was the second. Conclusion: G. corniculatum extracts suppress apoptosis in dPC12 cells and allocriptopine, oleamide, and 2-monopalmitin may be responsible of apoptosis suppressive effect.
dc.description.sponsorshipGazi University Scientific Research Projects Unit [05/2017-01]
dc.description.sponsorshipThis research was supported by the Gazi University Scientific Research Projects Unit (05/2017-01).
dc.identifier.doi10.4103/pm.pm_348_20
dc.identifier.endpage75
dc.identifier.issn0973-1296
dc.identifier.issn0976-4062
dc.identifier.issue73
dc.identifier.startpage67
dc.identifier.urihttps://doi.org/10.4103/pm.pm_348_20
dc.identifier.urihttps://hdl.handle.net/20.500.12868/4845
dc.identifier.volume17
dc.identifier.wosWOS:000670584400010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofPharmacognosy Magazine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectAlkaloids
dc.subjectapoptosis
dc.subjectchemical composition
dc.subjectfatty acids
dc.subjectGlaucium corniculatum
dc.subjectPC12 cell
dc.titleChemical Composition and Neurotherapeutic Potential of Glaucium corniculatum Extracts
dc.typeArticle

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