Relationship Between Blood and Pericardial Signal Peptide-CUB (complement C1r / C1s, Vegf and Bmp 1) -EGF (epidermal growth factor)-like Protein-1 (SCUBE-1) Levels and Ventricular Functions in Coronary Artery Bypass Patients
Yükleniyor...
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: Signal peptide-CUB (complement C1r/C1s, Uegf, and Bmp1)-EGF (epidermal growth factor)- like do- main- containing protein 1(SCUBE-1) is a cell surface protein studied as a biomarker in thrombosis and ischemia conditions and secreted at currently studied early embryogenesis. The aim of this study is to investigate the rela- tionship between left ventricular functions and pericardial / serum SCUBE-1 values of patients who underwent cor- onary artery bypass surgery. Materials and Methods: Forty patients who underwent cardiopulmonary bypass graft surgery were included in the study. Detailed echocardiographic findings of the patients were made before the operation. Left ventricular dys- function markers were determined according to left ventricular fracshortening. SCUBE-1 levels were studied with ELISA kits in blood plasma and pericardial fluid samples. SCUBE-1 levels were statistically compared between the determined groups. Results: Statistical differences were observed in LVDs, IVSd, neutrophil, RBC, CK-MB, troponin-I and WBC values in low and high FS groups (p <0.05). SCUBE-1 plasma levels did not differ statistically between the FS groups (p> 0.05). The same situation was similar for pericardial fluid levels (p> 0.05). Correlation was seen between SCUBE-1 plasma levels and SCUBE-1 pericardial levels (p <0.05). There was no significant correlation between echocardiographic findings and SCUBE-1 levels (p> 0.05). Conclusions: These results showed us that SCUBE-1 plasma and the pericardial fluid levels had no effect on the left ventricular dysfunction. SCUBE-1 is not one of the currently identified markers of cardiac dysfunction. Future studies will further increase our knowledge on this subject.
Açıklama
Anahtar Kelimeler
SCUBE-1, Coronary Artery Bypass, Left Ventricular Functions, Koroner Arter Baypas, Sol Ventrikül Fonksiyonları
Kaynak
Harran Üniversitesi Tıp Fakültesi Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
18
Sayı
3
Künye
Bağlantı
https://search.trdizin.gov.tr/tr/yayin/detay/1133847/relationship-between-blood-and-pericardial-signal-peptide-cub-complement-c1r-c1s-vegf-and-bmp-1-egf-epidermal-growth-factor-like-protein-1-scube-1-levels-and-ventricular-functions-in-coronary-artery-bypass-patients
https://hdl.handle.net/20.500.12868/2252
https://hdl.handle.net/20.500.12868/2252
