Investigation of Inflammation and Autophagy due to Biglycanmediated TLR2/4 Signaling in Oral Lichen Planus Tissues

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dc.contributor.authorGünizi, Özlem Ceren
dc.contributor.authorGünizi, Hüseyin
dc.contributor.authorEcıroglu, Hamıyet
dc.contributor.authorYıldız, Fatma
dc.date.accessioned2026-01-24T12:01:07Z
dc.date.available2026-01-24T12:01:07Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractObjective: Oral lichen planus (OLP) is a chronic oral mucosal disease of unknown etiology. Cellular immune response, basement membrane, and extracellular matrix (ECM) molecules are also noteworthy in the pathogenesis. We aimed to investigate the role of Biglycan (BGN) in Toll-like receptors (TLR)2/4- CD14 and TLR4-CD44 mediated signaling mechanisms in the pathogenesis of OLP. Methods: Twenty-one patients with a previous diagnosis of OLP and 21 patients with normal oral mucosa were included. RNA was isolated from biopsy samples of patients, and the gene expression of BGN, TLR2, TLR4, CD14, and CD44 was analyzed by quantitative real-time polymerase chain reaction and immunohistochemistry. Results: According to our findings, the fold change rates of BGN, TLR2, TLR4, and CD14 mRNA levels in tissues obtained from patients with OLP were higher compared with the control group. TLR2, TLR4, and CD14 fold change rates were statistically significant (p<0.05). CD44 co-receptor mRNA levels were higher in the control group (p<0.05). Similar results were obtained by immunohistochemical analysis. Conclusion: BGN expression has a pro-inflammatory effect in various disease models. The BGN levels in the tissues of patients with OLP were higher than those of the control group, but the difference was not statistically significant. However, TLR2/4-CD14 and CD44 levels were upregulated, as well as CD44 levels were downregulated. We suggest that inflammation signaling is activated and autophagy is inhibited in OLP. BGN-dependent inflammation and autophagy signaling in OLP are evaluated for the first time.
dc.identifier.doi10.4274/forbes.galenos.2024.59389
dc.identifier.endpage122
dc.identifier.issn2717-9443
dc.identifier.issn2757-5241
dc.identifier.issue2
dc.identifier.startpage116
dc.identifier.trdizinid1277730
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1277730
dc.identifier.urihttps://doi.org/10.4274/forbes.galenos.2024.59389
dc.identifier.urihttps://hdl.handle.net/20.500.12868/4016
dc.identifier.volume5
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofForbes tıp dergisi (Online)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR-Dizin_20260121
dc.subjectInflammation
dc.subjectautophagy
dc.subjectoral lichen planus
dc.subjectTLR
dc.subjectBiglycan
dc.titleInvestigation of Inflammation and Autophagy due to Biglycanmediated TLR2/4 Signaling in Oral Lichen Planus Tissues
dc.typeArticle

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