Evaluation of Anticancer and Antimicrobial Potentials of Tarantula cubensis Venom (Theranekron® D6)

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dc.contributor.authorTosun, Nazan Gökşen
dc.contributor.authorKaplan, Ozlem
dc.contributor.authorOzgur, Aykut
dc.date.accessioned2026-01-24T12:01:05Z
dc.date.available2026-01-24T12:01:05Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractTarantula cubensis venom (Theranekron®D6) is widely used in veterinary medicine as a drug with anti-tumor, wound healing, anti-inflammatory, antiphlogistic properties. The purpose of the study was to explore Theranekron®D6 (TD6)'s antibacterial activity and its impact on apoptotic cell death in human colon and liver cancer cell lines. TD6 showed a dose and time dependent cytotoxic effect at 12h and 24h in HT-29 and HUH-7 cancer cell lines. The IC50 values of TD6 were calculated as 12.18 µg/mL and 25.10 µg/mL in HT-29 and HUH-7 cell lines at 24h, respectively. TD6 induced apoptosis in HT-29 and HUH-7 cell lines. In these cells exposed to TD6, while the BAX/BCL-2 ratio and CASP-3 mRNA level increased, the HSP90 mRNA and protein level decreased. Also, TD6 exhibited antimicrobial activities against Pseudomonas aeruginosa, Enterococcus faecalis, Klebsiella pneumonia, Staphylococcus aureus, Candida albicans and Candida utilis. Obtained results demonstrated that TD6 has great potentials as alternative therapeutic for cancer and infectious diseases as apoptosis inducer and antimicrobial agent.
dc.identifier.doi10.18185/erzifbed.1463282
dc.identifier.endpage637
dc.identifier.issn1307-9085
dc.identifier.issn2149-4584
dc.identifier.issue3
dc.identifier.startpage626
dc.identifier.trdizinid1296522
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1296522
dc.identifier.urihttps://doi.org/10.18185/erzifbed.1463282
dc.identifier.urihttps://hdl.handle.net/20.500.12868/3984
dc.identifier.volume17
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofErzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR-Dizin_20260121
dc.subjectAntifungal
dc.subjectTarantula cubensis
dc.subjectApoptosis
dc.subjectCancer
dc.subjectAntibacterial
dc.titleEvaluation of Anticancer and Antimicrobial Potentials of Tarantula cubensis Venom (Theranekron® D6)
dc.typeArticle

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