Laboratory Parameters Predicting Brain Metastasis in Patients with Lung Cancer

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dc.contributor.authorTugrul, Fuzuli
dc.contributor.authorBeypınar, İsmail
dc.contributor.authorUçan, Anıl
dc.date.accessioned2026-01-24T12:20:46Z
dc.date.available2026-01-24T12:20:46Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractOBJECTIVE Lung cancer (LC) is the leading cause of cancer death worldwide. Multiple studies have shown tumor progression and prognosis to be associated with immune status and nutritional condition. Alterations in blood lipid levels have been demonstrated to be a risk factor for LC. In the present study, we evaluate the effect of blood parameters on brain metastasis in LC. METHODS Patients identified with brain metastases during diagnosis or therapy and who subsequently underwent radiation therapy were included in the study. Patient characteristics, laboratory parameters, pathologic subtype, disease stage, treatment modalities, and outcome following treatment were recorded, and the patients’ PFS and OS were calculated. RESULTS Univariate analysis revealed neutrophil, low-density lipoprotein (LDL), neutrophil-to-lymphocyte ratio (NLR), and C-reactive protein levels to be significantly different between groups according to brain metastases. In a subgroup analysis based on cancer subtypes, LDL and lymphocyte levels were found to be significantly different in squamous cancer, while LDL was different in the undifferentiated subtype. OS was different in the NLR low and high groups, favoring the NLR low group (p=0.015; OS: 12 vs. 9 months), and the monocyte/lymphocyte ratio was significant in terms of OS favoring the low group with a cutoff value of 0.56 (p=0.002; OS: 13 vs. 9 months). CONCLUSION Our study identified differences in the inflammatory and lipid profiles of LC patients in terms of brain metastases and survival. Other than the literature, LDL levels were different among groups and may be considered a valid subject for future study. © 2024, Turkish Society for Radiation Oncology.
dc.identifier.doi10.5505/tjo.2023.3943
dc.identifier.endpage68
dc.identifier.issn1300-7467
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85186864212
dc.identifier.scopusqualityQ4
dc.identifier.startpage63
dc.identifier.urihttps://doi.org/10.5505/tjo.2023.3943
dc.identifier.urihttps://hdl.handle.net/20.500.12868/4571
dc.identifier.volume39
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherIstanbul Tip Fakultesi
dc.relation.ispartofTurk Onkoloji Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20260121
dc.subjectBrain metastasis
dc.subjectlaboratory parameters
dc.subjectlipid profile
dc.subjectlung cancer
dc.titleLaboratory Parameters Predicting Brain Metastasis in Patients with Lung Cancer
dc.typeArticle

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