Investigation of Insulin-Like Growth Factor 1 Receptor Expression in Cases of Sacrococcygeal Pilonidal Sinus

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dc.contributor.authorAvcı, Sema
dc.contributor.authorŞahin, Sevinç
dc.contributor.authorBalcı, Cemre Nur
dc.date.accessioned2026-01-24T12:01:19Z
dc.date.available2026-01-24T12:01:19Z
dc.date.issued2023
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractAim: This study aims to determine the role of IGF-1R in the etiology of sacrococcygeal pilonidal sinus and to evaluate the findings regarding its contribution to treatment. Material and Methods: The general structure of skin and connective tissue components in healthy and lesioned tissue sections of sacrococcygeal pilonidal sinus cases was evaluated by Masson trichrome staining. In addition, the expression of IGF-1R protein in healthy and pilonidal sinus tissue was determined by immunohistochemical staining. Results: It was observed that the epidermis of the pilonidal sinus was thinned compared to the healthy area, and the hair follicle structures and connective tissue components deteriorated. IGF-1R expression was significantly decreased in basal keratinocytes in sacrococcygeal pilonidal sinus tissues. Conclusion: It is thought that IGF-1R may be involved in the etiology of sacrococcygeal pilonidal sinus, and more data is needed in terms of its contribution to treatment.
dc.identifier.doi10.37990/medr.1285358
dc.identifier.endpage488
dc.identifier.issn2687-4555
dc.identifier.issue3
dc.identifier.startpage483
dc.identifier.trdizinid1263427
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1263427
dc.identifier.urihttps://doi.org/10.37990/medr.1285358
dc.identifier.urihttps://hdl.handle.net/20.500.12868/4203
dc.identifier.volume5
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofMedical records-international medical journal (Online)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR-Dizin_20260121
dc.subjectSacrococcygeal Pilonidal Sinus
dc.subjectIGF-1R
dc.subjectkeratinocytes
dc.titleInvestigation of Insulin-Like Growth Factor 1 Receptor Expression in Cases of Sacrococcygeal Pilonidal Sinus
dc.typeArticle

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