In vivo wound-healing and in vitro antibacterial and antioxidant properties of Carduus adpressus extract

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dc.contributor.authorŞakul, Ayşe Arzu
dc.contributor.authorAyla, Şule
dc.contributor.authorOkur, Mehmet Evren
dc.contributor.authorKaradağ, Ayşe Esra
dc.contributor.authorDaylan, Benay
dc.contributor.authorGüzel, Elif
dc.contributor.authorÖzdemir, Ekrem Musa
dc.contributor.authorGünal, Mehmet Yalçın
dc.date.accessioned2023-07-31T13:11:11Z
dc.date.available2023-07-31T13:11:11Z
dc.date.issued2023
dc.departmentALKÜ, Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractCarduus adpressus has been used for its anti-hair loss effect in traditional folk medicine. The plant species is mainly distributed in Türkiye, Bulgaria, and the Western Caucasus. The studies on this specific plant in the genus Carduus is limited which remarks the significance of the current study. This study aims to investigate the antibacterial, antioxidant, and wound-healing properties of the methanolic extract of Carduus adpressus. Extract was obtained by maceration. The broth microdilution assay was performed on Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, and Escherichia coli. DPPH and ABTS radical scavenging assays were performed to detect the antioxidant capacity. Wound-healing activity was tested using alloxan-induced diabetic BALB-c mice. 4 groups, control, vehicle, CAE and Carduus adpressus groups were treated with the relative agent for 10 days. Extract demonstrated 62.5 µg/mL MIC against S. aureus and E. faecalis, and 125 µg/mL MIC against P. aeruginosa and E. coli. ABTS assay showed higher antioxidant activity compared to the DPPH assay. Carduus adpressus group demonstrated strong regeneration, epithelisation, and angiogenesis compared to the control group on day 10. Additionally, expression of PDGF, VEGF, and collagen formation was increased in the Carduus adpressus group compared to the control group on day 10. Extract demonstrated strong antibacterial, antioxidant, and wound-healing activities which indicate that it could be a source in developing wound-healing agents.
dc.identifier.doi10.29228/jrp.349
dc.identifier.endpage676en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage665en_US
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85151389912&origin=resultslist&sort=plf-f&src=s&nlo=&nlr=&nls=&sid=20c4fe371b9b908d4f7e419f791331ff&sot=aff&sdt=cl&cluster=scofreetoread%2c%22all%22%2ct&sl=72&s=AF-ID%28%22Alanya+Alaaddin+Keykubat+University%22+60198720%29+AND+SUBJAREA%28MEDI%29&relpos=28&citeCnt=0&searchTerm=
dc.identifier.urihttps://hdl.handle.net/20.500.12868/2341
dc.identifier.urihttps://jrespharm.com/abstract.php?id=1228
dc.identifier.volume27en_US
dc.indekslendigikaynakScopus
dc.language.isoen
dc.relation.ispartofJournal of Research in Pharmacy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntibacterial
dc.subjectAntioxidant
dc.subjectCarduus adpressus
dc.subjectExtract
dc.subjectBALB-c mice
dc.subjectWound-healing
dc.titleIn vivo wound-healing and in vitro antibacterial and antioxidant properties of Carduus adpressus extract
dc.typeArticle

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