The Oxidative and Anti-Angiogenic Effects of Acrylamide in Chorioallantoic Membrane Model

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dc.contributor.authorSozen, Mehmet Enes
dc.contributor.authorAkkaya, Özgür
dc.contributor.authorSavas, Hasan Basri
dc.contributor.authorKarahan, Oguz
dc.date.accessioned2026-01-24T12:00:54Z
dc.date.available2026-01-24T12:00:54Z
dc.date.issued2023
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractObjective: Acrylamide (ACR) is formed spontaneously during the preparation of carbohydrate-containing foods by exposure to high heat and can be found in large amounts in processed ready-made foods like potato crisps, biscuits, crackers, and bread. ACR is a toxic substance and increases oxidative stress. The aim of the study is to show the effects of ACR exposure at different doses on angiogenesis and oxidant-antioxidant balance in the chorioallantoic membrane (CAM) model. Methods: Two different concentrations of ACR were prepared (10-3 M and 10-4 M). Pellets were placed on the CAM of the embryos. Liquid samples were taken from fertilized chicken eggs before and after the experiment. Anti-angiogenic effects were evaluated through the window that was opened on the eggshell. Results: The 10-4 M ACR group caused anti-angiogenic effects (average score 0.3) which were higher than the control group, but these changes were not statistically significant. The 10-3 M ACR group caused moderate anti-angiogenic effects (average score 0.6). The 10-6 M Bevacizumab group caused powerful anti-angiogenic effects (average score 1). There is a significant increase in total oxidant capacity (TOC) and oxidative stress index (OSI) values in 10-3 M ACR and 10-4 M ACR groups, compared to the control group. Although there was a numerical increase in TOC and OSI values in 10-3 M ACR group compared to 10-4 M ACR group, this increase was not statistically significant. Conclusion: This study is the first to investigate the anti-angiogenic effects of ACR and is one of the first to investigate oxidative stress in the CAM model. ACR exposure increased oxidative stress in the CAM model and showed a dose-dependent anti-angiogenic effect.
dc.identifier.doi10.53394/akd.1015590
dc.identifier.endpage168
dc.identifier.issn1300-1779
dc.identifier.issn2687-2781
dc.identifier.issue2
dc.identifier.startpage162
dc.identifier.trdizinid1170821
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1170821
dc.identifier.urihttps://doi.org/10.53394/akd.1015590
dc.identifier.urihttps://hdl.handle.net/20.500.12868/3820
dc.identifier.volume9
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofAkdeniz Tıp Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR-Dizin_20260121
dc.subjectAntioxidant
dc.subjectAngiogenesis
dc.subjectAcrylamide
dc.subjectOxidant
dc.subjectChorioallantoic membrane model
dc.titleThe Oxidative and Anti-Angiogenic Effects of Acrylamide in Chorioallantoic Membrane Model
dc.typeArticle

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