The effect of Resveratrol on sphingosine-1 and Oxidative/ Nitrosative stress in an experimental heart ischemia reperfusion model

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dc.contributor.authorAvnioğlu, Seda
dc.contributor.authorGüngör, Meltem
dc.contributor.authorKurutaş, Ergül
dc.contributor.authorÖztürk, Ünal
dc.contributor.authorDemirhan, İlter
dc.contributor.authorBakaris, Sevgi
dc.contributor.authorVelioğlu, Halil Aziz
dc.contributor.authorÇankaya, Şeyda
dc.contributor.authorYuluğ, Burak
dc.date.accessioned2022-09-12T10:26:43Z
dc.date.available2022-09-12T10:26:43Z
dc.date.issued2022
dc.departmentALKÜ, Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractObjectives: Resveratrol (RSV) is a natural polyphenolic compound showing significant antioxidant effects. In this study, we aimed to investigate the effects of resveratrol on the sphingosine-1-phosphate (S1P) and oxidative stress biomarkers in hearth ischemia-reperfusion (I/R). Materials and Methods: The biochemical and histopathological effects of RSV on cardiac ischemia-reperfusion injury were investigated through ELISA- and light microscope. Results: We observed statistically significant differences between the treatment group and the control group in terms of malondialdehyde (MDA) level, catalase (CAT) and superoxide dismutase (SOD) activities (p<0.05). Histopathologically, we also observed decreased Polymorphonuclear Leucocyte (PMNL) infiltration, myocardial edema, miyositolysis in the treatment group compared to the I/R and sham groups. Conclusion: Resveratrol may play an important role in cardiac I/R injury through its anti-inflammatory and antioxidant effects which were biochemically and histopathologically confirmed in the present study.
dc.identifier.doi10.2478/rrlm-2021-0036
dc.identifier.endpage18en_US
dc.identifier.issue1en_US
dc.identifier.startpage9en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12868/1528
dc.identifier.urihttps://sciendo.com/article/10.2478/rrlm-2021-0036
dc.identifier.volume30en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.relation.ispartofRevista Romana de Medicina de Laborator
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectresveratrol
dc.subjectischemia/reperfusion injury
dc.subjectantioxidant
dc.subjectoxidative stress
dc.subjectheart
dc.titleThe effect of Resveratrol on sphingosine-1 and Oxidative/ Nitrosative stress in an experimental heart ischemia reperfusion model
dc.typeArticle

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