Differentiation of claustrum resting-state functional connectivity in healthy aging, Alzheimer's disease, and Parkinson's disease

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dc.contributor.authorAyyıldız, Sevilay
dc.contributor.authorVelioğlu, Halil Aziz
dc.contributor.authorAyyıldız, Behçet
dc.contributor.authorSütçübaşı, Bernis
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorBayraktaroğlu, Zübeyir
dc.contributor.authorYıldırım, Süleyman
dc.contributor.authorAtasever, Alper
dc.contributor.authorYuluğ, Burak
dc.date.accessioned2023-07-31T13:09:26Z
dc.date.available2023-07-31T13:09:26Z
dc.date.issued2023
dc.departmentALKÜ, Fakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractThe claustrum is a sheet-like of telencephalic gray matter structure whose function is poorly understood. The claustrum is considered a multimodal computing network due to its reciprocal connections with almost all cortical areas as well as subcortical structures. Although the claustrum has been involved in several neurodegenerative diseases, specific changes in connections of the claustrum remain unclear in Alzheimer's disease (AD), and Parkinson's disease (PD). Resting-state fMRI and T1-weighted structural 3D images from healthy elderly (n = 15), AD (n = 16), and PD (n = 12) subjects were analyzed. Seed-based FC analysis was performed using CONN FC toolbox and T1-weighted images were analyzed with the Computational Anatomy Toolbox for voxel-based morphometry analysis. While we observed a decreased FC between the left claustrum and sensorimotor cortex, auditory association cortex, and cortical regions associated with social cognition in PD compared with the healthy control group (HC), no significant difference was found in alterations in the FC of both claustrum comparing the HC and AD groups. In the AD group, high FC of claustrum with regions of sensorimotor cortex and cortical regions related to cognitive control, including cingulate gyrus, supramarginal gyrus, and insular cortex were demonstrated. In addition, the structural results show significantly decreased volume in bilateral claustrum in AD and PD compared with HC. There were no significant differences in the claustrum volumes between PD and AD groups so the FC may offer more precise findings in distinguishing changes for claustrum in AD and PD. © 2022 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
dc.identifier.doi10.1002/hbm.26171
dc.identifier.endpage1750en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage1741en_US
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85144158480&origin=resultslist&sort=plf-f&src=s&nlo=&nlr=&nls=&sid=20c4fe371b9b908d4f7e419f791331ff&sot=aff&sdt=cl&cluster=scofreetoread%2c%22all%22%2ct&sl=72&s=AF-ID%28%22Alanya+Alaaddin+Keykubat+University%22+60198720%29+AND+SUBJAREA%28MEDI%29&relpos=14&citeCnt=1&searchTerm=
dc.identifier.urihttps://hdl.handle.net/20.500.12868/2329
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1002/hbm.26171?src=getftr&utm_source=scopus&getft_integrator=scopus
dc.identifier.volume44en_US
dc.indekslendigikaynakScopus
dc.language.isoen
dc.relation.ispartofHuman Brain Mapping
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAlzheimer's disease
dc.subjectClaustrum
dc.subjectClaustrum
dc.subjectElderly people
dc.subjectFunctional connectivity
dc.subjectParkinson's disease
dc.titleDifferentiation of claustrum resting-state functional connectivity in healthy aging, Alzheimer's disease, and Parkinson's disease
dc.typeArticle

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