Histopathological Overview of Experimental Ulcer Models

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dc.contributor.authorToktay, Erdem
dc.contributor.authorSelli, Jale
dc.date.accessioned2023-06-08T11:11:51Z
dc.date.available2023-06-08T11:11:51Z
dc.date.issued2022
dc.departmentALKÜ, Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractHistopathology is the process of examining tissue that includes all the changes, when a diseased tissue shows compared to a healthy group with a result of a histological observation. Histopathology has become an essential process in medical experimental research and medical experimental models. Scientists have developed medical experimental animal models for these reasons and have pioneered new drug research for many years. One of these experimental researches is experimental ulcer models. This model, which was initially a single method, has led to the emergence of new models with the discovery of physiological processes on ulcers by scientists. Nowadays, researchers have performed many new peptic ulcer models on experimental animals over the years. The main point in the creation of the ulcer model is the increase in the stomach acid level and the removal or corruption of the gastric mucus. When the experimental models were examined histopathologically, it was seen that the most severe models were those induced by pyloric ligation, acetic acid application, and indomethacin. In these models, ulcer foci that progressed to the submucosa were common, while the superficial damage spreading to the entire surface was striking in the ethanol model. While epithelial losses are shown on the surface of the mucosa, foci of necrotic apoptotic cell clusters extending to the submucosa are shown according to the weight of the model. In addition, evidence of inflammation has been shared in almost all studies. All these results show that ulcer models can be created by many different mechanisms. However, similar findings were observed in almost all experiments. Whether the experimental model caused severe or mild ulceration changed the histological findings.
dc.identifier.doi10.5152/eurasianjmed.2022.22312
dc.identifier.endpage126en_US
dc.identifier.issue1en_US
dc.identifier.startpage120en_US
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1174683/histopathological-overview-of-experimental-ulcer-models
dc.identifier.urihttps://hdl.handle.net/20.500.12868/2227
dc.identifier.volume54en_US
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofEurasian Journal of Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHistopathology
dc.subjectExperimental Ulcer Models
dc.subjectIndomethacin
dc.subjectAcetic Acid
dc.subjectPyloric Ligation
dc.subjectEthanol Stress
dc.titleHistopathological Overview of Experimental Ulcer Models
dc.typeArticle

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