Nicotinamide Riboside Preserves Ovarian Injury in an Experimental Sepsis Model in Rats

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dc.contributor.authorSelli, Jale
dc.contributor.authorDilek, Vural Keleş
dc.contributor.authorKeleş, Osman Nuri
dc.contributor.authorÇelik, Muhammet
dc.contributor.authorYetim, Zeliha
dc.date.accessioned2026-01-24T12:01:05Z
dc.date.available2026-01-24T12:01:05Z
dc.date.issued2023
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractObjective: The aim of the study is to investigate the protective effects of nicotinamide riboside on oxidative stress in an experimental sepsis model created by cecal ligation and puncture. Materials and Methods: Rats were divided into 3 groups randomly: sham-operated (control) group, sep sis group, and nicotinamide riboside-treated group. Sepsis model-induced cecal ligation and puncture was applied to sepsis group rats. Animals in the nicotinamide riboside-treated group were administered nicotin amide riboside intraperitoneally (500 mg/kg). Tissue specimens from rats were biochemically calculated for their activities of catalase, superoxide dismutase, glutathione peroxidase, myeloperoxidase, and malondialde hyde levels. Ovarian tissues of all rats were histopathologically evaluated. Results: Catalase, superoxide dismutase, and glutathione peroxidase activities were lower in the sepsis group compared to the sham-operated (control) group. Superoxide dismutase activity was significantly higher in the nicotinamide riboside-treated group than in control and sepsis group (P < .05). Myeloperoxidase activi ties and mean malondialdehyde concentration of ovarian tissue were lower in nicotinamide riboside-treated group than in sepsis group (P < .05). The light microscopic assessment revealed that ovarian tissue was protected, and inflammation and interstitial edema decreased in nicotinamide riboside-treated group. The follicular damage findings were notably decreased in nicotinamide riboside-treated group in comparison to sepsis group (P<0.05). Conclusion: Our findings indicated that nicotinamide riboside diminished ovarian injury in sepsis via inhibiting tissue infiltration and increasing endogenous antioxidant capacity. Nicotinamide riboside administration may represent a new treatment approach for the prevention of sepsis-induced ovarian injury
dc.identifier.doi10.5152/eurasianjmed.2023.22255
dc.identifier.endpage134
dc.identifier.issn1308-8734
dc.identifier.issn1308-8742
dc.identifier.issue2
dc.identifier.startpage128
dc.identifier.trdizinid1188010
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1188010
dc.identifier.urihttps://doi.org/10.5152/eurasianjmed.2023.22255
dc.identifier.urihttps://hdl.handle.net/20.500.12868/3991
dc.identifier.volume55
dc.indekslendigikaynakTR-Dizin
dc.language.isotr
dc.relation.ispartofEurasian Journal of Medicine
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR-Dizin_20260121
dc.subjectKlinik Nöroloji
dc.titleNicotinamide Riboside Preserves Ovarian Injury in an Experimental Sepsis Model in Rats
dc.typeArticle

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