In silico Prediction and In vitro Antioxidant Activities of Two Jujube Fruits from Different Regions

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dc.contributor.authorUçkaya, Fatih
dc.date.accessioned2023-07-28T14:02:16Z
dc.date.available2023-07-28T14:02:16Z
dc.date.issued2022
dc.departmentALKÜ, Fakülteler, Sağlık Bilimleri Fakültesi, Hemşirelik Bölümü
dc.description.abstractJujube is a fruit rich in antioxidant compounds and vitamin C. In this way, it can prevent cell damage by fighting free radicals. In the study, antioxidant activities, total phenolic and total flavonoid compound amounts of methanolic extracts of jujube fruits were determined. In addition, their biochemical compositions were determined using HPLC. Also, an in silico prediction study of the identified active ingredients was performed to evaluate antioxidant, antiradical, antibacterial, antifungal, anti-inflammatory, antimutagenic, and membrane integrity antagonist properties. For the determination of antioxidant capacity, ferric reducing power (FRAP) and cupric ion reducing capacity (CUPRAC), DPPH radical scavenging activity and ?-carotene-linoleic acid assay were used. The amounts of total phenolic and the total flavonoid compounds of the extracts were determined as gallic acid equivalent (GAE) and as quercetin equivalent (QE). The methanolic extract of jujube collected from Antalya contains 580 ?g GAE.mg-1 and 240 ?g QE.mg-1, and the methanolic extract of jujube collected from Denizli contains 900 ?g GA.mg-1 and 380 ?g QE.mg-1. The IC50 values of Antalya and Denizli methanolic extracts according to the DPPH scavenging assay were 10.34 and 9.82, respectively. Gallic acid, catechin, caffeic acid, coumaric acid, ferulic acid and cinnamic acid were detected by HPLC. In addition, the in silico effects of these molecules were estimated with the PASS online prediction program. As a result, it was seen that Denizli jujube had a higher antioxidant effect than Antalya jujube.
dc.identifier.doi10.46810/tdfd.1113447
dc.identifier.endpage23en_US
dc.identifier.issue3en_US
dc.identifier.startpage12en_US
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1127648/in-silico-prediction-and-in-vitro-antioxidant-activities-of-two-jujube-fruits-from-different-regions
dc.identifier.urihttps://hdl.handle.net/20.500.12868/2309
dc.identifier.volume11en_US
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofTĂĽrk DoÄźa ve Fen Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntioksidan Activity
dc.subjectDPPH
dc.subjectFRAP
dc.subjectCUPRAC
dc.subjectPASSonline
dc.subjectZiziphus
dc.subjectJujuba
dc.titleIn silico Prediction and In vitro Antioxidant Activities of Two Jujube Fruits from Different Regions
dc.typeArticle

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