Protective effect of daidzein on ovarian ischemia-reperfusion injury in rats

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dc.contributor.authorToktay, Erdem
dc.contributor.authorGürbüz, Muhammet Ali
dc.contributor.authorBal, Tuğba
dc.contributor.authorÖzgül, Özlem
dc.contributor.authorErba, Elif
dc.contributor.authorUğan, Rüstem Anıl
dc.contributor.authorSell, Jale
dc.date.accessioned2022-09-12T10:30:28Z
dc.date.available2022-09-12T10:30:28Z
dc.date.issued2022
dc.departmentALKÜ, Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractAbstract Purpose: In this study, our aim was to investigate the potential effects of strong antioxidant daidzein (DZ) on ovarian ischemia and reperfusion injury. Materials and Methods: A total of 42 female Sprague-Dawley rats were randomly divided into seven groups. For the experimental model, the clamps were removed after 3 hours of ischemia, and blood flow was provided again. Then, reperfusion process was terminated for 3 hours. Daidzein was orally administered to animals at doses of 35 and 70 mg/kg 30 minutes before ischemia (I) and ischemia and reperfusion (I/R) procedures. Results: Severe immunoreactivity of the IL-1 beta, IL-6 and Caspase-3 were detected in I and I/R groups. Moderate immunoreactivity of IL-1 beta, IL-6 and Caspase-3 was detected in I+DZ35 and I/R+DZ35 groups, and slightly positivity was detected in I+DZ70 and I/R+DZ70 groups. The SOD activity level increased in the groups treated with Daidzein, while MDA levels decreased. In addition, hemorrhage areas and inflammatory cell migration decreased in I/R+DZ70 and I/R+DZ35 groups, when compared to I/R group in a dose dependent manner. Conclusion: Daidzein has a strong protective role in the treatment of ovarian ischemia-reperfusion injury and can be used as a therapeutic agent.
dc.identifier.doi10.17826/cumj.993250
dc.identifier.endpage110en_US
dc.identifier.issue1en_US
dc.identifier.startpage102en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12868/1556
dc.identifier.volume47en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.relation.ispartofÇukurova Medical Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDaidzein
dc.subjectOvary
dc.subjectIschemia
dc.subjectReperfusion injury
dc.subjectRat
dc.titleProtective effect of daidzein on ovarian ischemia-reperfusion injury in rats
dc.typeArticle

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