THE EFFECTS OF LONG-ACTING METHYLPHENIDATE FORMULATIONS AND ATOMOXETINE ON CARDIAC FUNCTIONS IN CHILDREN WITH ATTENTION DEFICIT AND HYPERACTIVITY
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Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Methylphenidate (MPH) and atomoxetine (ATX) are most commonly prescribed for the treatment of attention deficit hyperactivity disorder (ADHD). In the literature, there are studies performed to evaluate each of these drugs, but there is no study comparing these three medications together. Therefore, we aimed to evaluate the cardiac effects of these medications. Methods: Forty-six children with ADHD using osmotic-release oral system MPH (OROS-MPH), 46 using extended-release MPH (ER-MPH), and 46 using ATX for at least six months were included in the patient groups. Forty-six children with normal cardiac findings were enrolled as the control group. All participants were evaluated using a sociodemographic information form, 12-channel electrocardiography (ECG), transthoracic 2D, Doppler and tissue Doppler echocardiography. Results: Statistically significant differences were observed in terms of A wave velocity, E/A and E’ septal values between the groups (p=0.002, p<0.001, p=0.002, respectively). Children using ATX had higher A wave velocities than the OROS-MPH users and controls (p<0.001 and p=0.007, respectively) and lower E/A values than the OROS-MPH users and controls (p<0.001 for both). Children using ER-MPH and ATX had lower E’ septal values compared to the control group (p<0.001 and p=0.002, respectively). Conclusion: Atomoxetine treatment showed impairment in some of the myocardial relaxation parameters more than long acting-MPH medications. In conclusion, although the drugs used in the treatment of ADHD are cardiac safe in general and do not cause clinical findings of heart failure, patients should be evaluated for cardiac involvement. Further studies are needed to support the findings in our study
Açıklama
Anahtar Kelimeler
Children, attention deficit and hyperactivity disorder, Methylphenidate, Atomoxetine, tissue Doppler imaging
Kaynak
Acta Medica Nicomedia
WoS Q Değeri
Scopus Q Değeri
Cilt
6
Sayı
1
